SUPPLY, EVALUATION AND SELECTION OF LIVING RENAL DONORS

活体肾捐献者的供应、评估和选择

基本信息

项目摘要

Over 30,000 end-stage renal disease (ESRD) patients are waiting for cadaveric kidney transplantation. This number is expected to double in five years. In the last decease, the number of kidneys from cadaver donors has remained stagnant at 7,500-8,000/year. Although living renal donation is accepted as a low risk procedure with superior allograft survival, only 25% of transplants performed in European Americans and 10% of transplants in African americans are from living donors. factors governing the supply of living renal donors are not well understood. Despite well-established criteria for donor nephrectomy, variable which influence the outcomes of donor evaluation/selection process have not been rigorously studied. The goals of this project are to: (I) identify and describe the obstacles to the supply of living renal donors; (ii) identify the medical diagnoses, laboratory findings and non-medical factors which impact the outcomes of donor selection/evaluation process and ; (iii) analyze the relationships between the predictors of living renal donation and the characteristics of various ESRD populations. A quasi-experimental design with statistical adjustment for baseline characteristics will be applied. the sampling frame is a consecutive sample of three cohorts (transplant candidates, evaluable and unevaluable potential donors) from two transplants centers (University of Michigan and Henry Ford Hospitals). Clinical and laboratory investigations and multi-stage, longitudinal, interviewer-administered, validated survey instruments will be prospectively applied to 840 transplant candidates and 420 potential donors. Descriptive and multi variate techniques will be used to analyze the relationships between the probability of being a donor and 3 classes of explanatory variables: (1) demographics, cultural beliefs and socioeconomic characteristics; (2) medical diagnoses and serologies; and (3) ABO blood groups and positive crossmatch. The relationship between familial size and the pool of potential living donors will also be analyzed. A cohort of donors will be prospectively followed for overall health and renal outcomes. The proposed project will yield additional information needed to build effective public health campaigns to improve living donor awareness, increase the donor pool and bring the benefit of kidney transplantation to more ESRD patients, particularly the minority patients, among whom access to transplantation is an even greater problem. The prospective donor database will demonstrate the feasibility of a multi- center living renal donor registry which is essential to future research in living renal donation.
超过30,000名终末期肾病(ESRD)患者正在等待 尸体肾移植 预计这一数字将翻一番 在五年内。 在最后一个死亡病例中, 捐助者仍然停留在每年7 500 - 8 000人。 虽然生活 肾脏捐献被认为是一种低风险手术,具有上级 同种异体移植物存活率,只有25%的移植在欧洲进行, 美国人和10%的非洲裔美国人的移植来自 活体捐赠者 决定活体肾脏捐赠者供应的因素包括 没有被很好地理解。 尽管捐助者的标准已经确立, 肾切除术,影响供体结局的变量 评价/甄选程序尚未得到严格研究。 的 该项目的目标是:(一)识别和描述的障碍, 活体肾脏捐赠者的供应;(ii)确定医疗诊断, 实验室检查结果和影响结果的非医学因素 (三)对捐赠者的选择/评估过程进行分析; 活体肾脏捐献的预测因素与 不同ESRD人群的特征。 准实验 将对基线特征进行统计学调整的设计 应用。 抽样框架是三个群组的连续样本 (移植候选人,可评估和不可评估的潜在供体) 来自两个移植中心(密歇根大学和亨利福特 医院)。 临床和实验室研究以及多阶段, 纵向、访谈者管理、有效的调查工具 将适用于840名移植候选人和420名 潜在的捐助者。 将使用描述性和多变量技术 来分析成为捐赠者的概率 和3类解释变量:(1)人口统计学,文化 信仰和社会经济特征;(2)医疗诊断和 血清学;(3)ABO血型和阳性交叉配型。 的 家庭规模与潜在生活水平之间的关系 还将分析捐助者。 一批捐赠者将 前瞻性随访总体健康和肾脏结局。 的 拟议的项目将产生建立所需的额外信息 开展有效的公共卫生运动,提高对活体捐赠者的认识, 增加供体库,为肾移植带来效益 更多的ESRD患者,特别是少数民族患者, 他们接受器官移植是一个更大的问题。 的 未来的捐助者数据库将证明一个多- 中心活体肾供体登记处是未来研究的必要条件 活体肾脏捐赠

项目成果

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Akinlolu Oluseun Ojo其他文献

Akinlolu Oluseun Ojo的其他文献

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{{ truncateString('Akinlolu Oluseun Ojo', 18)}}的其他基金

University of Arizona - Banner Health Precision Medicine Initiative Cohort Enrollment Center
亚利桑那大学 - 横幅健康精准医学计划队列招生中心
  • 批准号:
    9228653
  • 财政年份:
    2016
  • 资助金额:
    $ 12.69万
  • 项目类别:
A Clinical Trial to Prevent New Onset Diabetes After Transplantation
预防移植后新发糖尿病的临床试验
  • 批准号:
    8162925
  • 财政年份:
    2011
  • 资助金额:
    $ 12.69万
  • 项目类别:
A Clinical Trial to Prevent New Onset Diabetes After Transplantation
预防移植后新发糖尿病的临床试验
  • 批准号:
    8472492
  • 财政年份:
    2011
  • 资助金额:
    $ 12.69万
  • 项目类别:
A Clinical Trial to Prevent New Onset Diabetes After Transplantation
预防移植后新发糖尿病的临床试验
  • 批准号:
    8330867
  • 财政年份:
    2011
  • 资助金额:
    $ 12.69万
  • 项目类别:
A Clinical Trial to Prevent New Onset Diabetes After Transplantation
预防移植后新发糖尿病的临床试验
  • 批准号:
    8677880
  • 财政年份:
    2011
  • 资助金额:
    $ 12.69万
  • 项目类别:
Chronic Renal Insufficiency Cohort (CRIC) Study
慢性肾功能不全队列 (CRIC) 研究
  • 批准号:
    7901940
  • 财政年份:
    2009
  • 资助金额:
    $ 12.69万
  • 项目类别:
HIGH DOSE FOLIC ACID, VITAMINS B6 & B12 ON ARTERIOSCLEROTIC CARDIOVASC OUTCOMES
高剂量叶酸、维生素 B6
  • 批准号:
    7603713
  • 财政年份:
    2007
  • 资助金额:
    $ 12.69万
  • 项目类别:
CHRONIC RENAL INSUFFICIENCY COHORT STUDY (CRIC)
慢性肾功能不全队列研究 (CRIC)
  • 批准号:
    7603738
  • 财政年份:
    2007
  • 资助金额:
    $ 12.69万
  • 项目类别:
CHRONIC RENAL INSUFFICIENCY COHORT STUDY (CRIC)
慢性肾功能不全队列研究 (CRIC)
  • 批准号:
    7376558
  • 财政年份:
    2006
  • 资助金额:
    $ 12.69万
  • 项目类别:
HIGH DOSE FOLIC ACID, VITAMINS B6 & B12 ON ARTERIOSCLEROTIC CARDIOVASC OUTCOMES
高剂量叶酸、维生素 B6
  • 批准号:
    7376516
  • 财政年份:
    2006
  • 资助金额:
    $ 12.69万
  • 项目类别:
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