SCREENING FOR OVARIAN CANCER--PSYCHOBEHAVIORAL OUTCOMES

卵巢癌筛查——心理行为结果

• 批准号: 6352111
• 负责人: MICHAEL A. ANDRYKOWSKI
• 金额: $ 0.82万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6352111
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; cognition; coping; emotions; female; human subject; longitudinal human study; mass screening; neoplasm /cancer diagnosis; outcomes research; ovary neoplasms; psychological aspect of cancer; ultrasonography

Early detection of ovarian cancer (OC) is critical to management of the disease. While transvaginal sonography (TVS) is the preferred screening modality for OC, concerns have been raised regarding the cost/benefit ratio associated with TVS. While TVS has been shown to facilitate early detection of OC, TVS yields a high proportion of "abnormal" findings. These findings require additional follow-up in the form of repeat TVS testing or exploratory surgery. While the vast majority of these abnormal findings are ultimately determined to be "false positives," the impact of this potentiallly stressful experience upon a woman's cognition, affect, and behavior has not been adequately examined. This study will use a prospective, longitudinal design to examine psychological and behavioral outcomes associated with TVS screening for OC. Three groups of women will be studied: women undergoing an initial TVS test who receive a normal result (n=300), women undergoing an initial TVS test who receive an abnormal result (n=300), and a matched group of healthy women who have never undergone TVS testing (n=300). Assessments will be conducted prior to initial TVS test and at 2 week, and 4, 18, and 30 month followups. Guided by the conceptual framework provided by both the Cognitive-Social Health Information Processing (C-SHIP) and Monitoring Process Models, endpoints to be examined include cognition (e.g., risk perception, perceptions of TVS efficacy, intrusive and avoidant ideation), affect (e.g., depression, mood disturbance), and behavior (adherence to routine follow-up TVS testing). Research aims include: (1) characterization of women who undergo TVS screening; (2) identification of psychological and behavioral outcomes associated with TVS screening; and (3) identification of clinical, demographic, and psychological variables associated with post-TVS psychological and behavioral outcomes. Regarding the latter aim, hypotheses regarding the relationship between informational coping style (e.g., high monitoring) and post-TVS psychological and behavioral outcomes will be tested. Results will enable development of interventions to enhance psychological and behavioral outcomes after TVS screening for OC.

卵巢癌(OC)的早期发现对该病的治疗至关重要。虽然经阴道超声(TVS)是卵巢癌的首选筛查方法，但与TVS相关的成本/效益比也引起了关注。虽然电视已被证明有助于OC的早期检测，但TVS会产生很高比例的“异常”发现。这些发现需要以重复TVS测试或探查手术的形式进行额外的随访。虽然这些异常发现中的绝大多数最终被确定为“假阳性”，但这种潜在的压力经历对女性的认知、情感和行为的影响还没有得到充分的研究。这项研究将使用前瞻性的纵向设计来检查与电视筛查OC相关的心理和行为结果。将对三组妇女进行研究：接受初步TVS检测但结果正常的女性(n=300)，接受初始TVS检测但结果不正常的女性(n=300)，以及从未接受过TVS检测的健康女性(n=300)。评估将在最初的TVS测试之前、2周以及4、18和30个月的随访中进行。在认知-社会健康信息加工(C-SHIP)和监控过程模型提供的概念框架的指导下，被检查的终点包括认知(例如，风险感知、对电视效果的感知、侵入性和回避性思维)、情感(例如，抑郁、情绪障碍)和行为(对电视节目常规跟踪测试的遵守情况)。研究目标包括：(1)对接受电视节目筛查的女性进行表征；(2)确定与电视节目筛查相关的心理和行为结果；(3)确定与电视节目后心理和行为结果相关的临床、人口统计学和心理变量。关于后一个目标，将测试关于信息性应对方式(例如，高监控)与电视后心理和行为结果之间关系的假设。结果将有助于制定干预措施，以提高电视节目筛查OC后的心理和行为结果。