QUALITY OF LIFE FOLLOWING BONE MARROW TRANSPLANTATION

骨髓移植(BMT)治疗多发性骨髓瘤的研究进展 近年来，危及生命的疾病显著增加。前瞻 骨髓移植后的长期存活率也有所增加。不过， 对幸存者所证明的生活质量知之甚少 异基因骨髓移植。关于幸存者的生活质量，我们一无所知。 自体骨髓移植。现有的很少的研究表明， 成年骨髓移植幸存者的生活质量。虽然一些患者表现出很少的 骨髓移植后的并发症和证据表明基本上“正常”的质量 生活中，其他患者表现出各种残留的困难。知识 骨髓移植后生活质量对于(A)知情的过程是必不可少的 同意，(B)确定骨髓移植后康复需求和 制定干预措施以提高骨髓移植后的生活质量，以及(C) 分析与BMT相关的相对成本和收益。使用 回顾，纵向设计，拟议的研究将评估 150例至少1年的成人骨髓移植患者的生活质量 在BMT之后。所有患者都将接受自体或异体移植。 骨髓移植是一种恶性疾病。BMT幸存者将从5个不同的人中选出 BMT中心。75例肾脏存活者的配对对照样本 移植(RT)也将被评估。骨髓移植患者将完成一项 电话采访和一包调查问卷在初始和 18个月的随访评估。RT患者将只完成一包 在两次评估中都有问卷调查。拟议方案的总体目标 研究是(A)确定成年人的生活质量 各种结果领域的BMT幸存者，包括 身体、社会、心理和职业，以及(B)身份认同 与患者、疾病和治疗相关的变量 骨髓移植后生活质量的患者间变异性。《公约》的具体目标 拟议的研究包括：(A)比较#年的生活质量结果 自体和异体骨髓移植幸存者，(B)颞叶检查 骨髓移植后功能恢复和生活质量的轨迹，以及(C) 骨髓移植后生活质量与存活者的比较 RT，一种类似的医疗程序，与先前建立的和 可接受的生活质量结果。

The use of bone marrow transplantation (BMT) as treatment for a variety of life threatening diseases has increased markedly in recent years. Prospects for longterm survival following BMT have also increased. Nevertheless, little is known about the quality of life evidenced by survivors of allogeneic BMT. Nothing is known about the quality of life of survivors of autologous BMT. The scant research that exists suggests wide variability in the quality of life of adult BMT survivors. While some patients exhibit few post-BMT complications and evidence an essentially "normal" quality of life, other patients evidence a variety of residual difficulties. Knowledge of post-BMT quality of life is essential for (a) the process of informed consent, (b) identification of post-BMT rehabilitation needs and the development of interventions to enhance post-BMT quality of life, and (c) analysis of the relative costs and benefits associated with BMT. Using a retrospective, longitudinal design, the proposed research will assess quality of life in a sample of 150 adult BMT patients at least 1 year post-BMT. All patients will have undergone either autologous or allogeneic BMT for a malignant disease. BMT survivors will be drawn from 5 different BMT centers. A matched comparison sample of 75 survivors of renal transplantation (RT) will also be assessed. BMT patients will complete a telephone interview and a packet of questionnaires at both an initial and 18-month follow-up assessment. RT patients will complete only the packet of questionnaires at both assessments. The overall aims of the proposed research are the (a) identification of the quality of life of adult survivors of BMT across a variety of outcome domains including the physical, social, psychological, and occupational, and (b) identification of patient-, disease-, and treatment-related variables associated with interpatient variability in post-BMT quality of life. Specific aims of the proposed research include (a) comparison of quality of life outcomes in survivors of autologous and allogeneic BMT, (b) examination of the temporal trajectory of post-BMT functional recovery and quality of life, and (c) comparison of post-BMT quality of life with that evidenced by survivors of RT, an analogous medical procedure with previously established and acceptable quality of life outcomes.