OCCUPATIONAL EXPOSURES AND RISK OF BREAST CANCER

职业暴露和乳腺癌风险

• 批准号: 6173553
• 负责人: John Edward Vena
• 金额: $ 12.42万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6173553
• 关键词: breast neoplasms; cancer risk; carbopolycyclic compound; clinical research; electromagnetic radiation; female; histology; human subject; interview; occupational health /safety; solvents; statistics /biometry; toxicology; women's health

Recent estimates indicate that only about 40 percent of breast cancer cases can be explained by accepted and suspected risk factors. Exposures to chemical and physical agents in the workplace of women have not been studied adequately. Thus, the object of the present protocol is to determine whether occupational exposures to selected chemical and physical agents is associated with increased risks of pre- and postmenopausal breast cancer. A population-based, case-control study of pre-and postmenopausal breast cancer incidence among women aged 40 to 79 years was conducted in western New York State between 1986 and 1991. Only new, histologically-confirmed primary cases of malignant breast cancer from all major hospitals in the region were enrolled (301 premenopausal and 439 postmenopausal). A population-based control group was recruited and was frequency-matched to case subjects on age and county of residence. Face-to-face interviews by trained nurse- interviewers were carried out and information on a wide array of accepted and potential risk factors was obtained. Standardized lifetime occupational histories were also obtained and these included details regarding place of employment, duties and activities associated with each job. For all 1,550 subjects, the job histories will be sent to a team of expert industrial hygienists and chemists at the Institut Armand-Frappier who will then attribute exposure to about 300 agents using a method developed by Siemiatycki and colleagues. The team has considerable experience in coding these types of job histories and will collaborate with hygienists in Buffalo. The occupational information present in the job descriptions is sufficiently detailed to capture the idiosyncracies of each person's job; thus, this system will minimize exposure misclassification. Statistical analyses, including logistic regression and generalized additive modeling techniques, will be carried out to assess the role of occupational exposures with a focus on polycyclic aromatic hydrocarbons, specific organic solvents and electromagnetic fields. Analyses will be conducted separately for the pre- and postmenopausal groups and will be combined where appropriate. Identification of agents whose exposures are amenable to modification may allow for new public health initiatives to reduce risk. This timely investigation should make an important contribution to our limited understanding of occupational risk factors for breast cancer.

最近的估计表明，只有大约40%的乳腺癌， 这些病例可以用公认的和怀疑的风险因素来解释。 妇女在工作场所接触化学和物理制剂， 没有得到充分的研究。 因此，本议定书的目的 是为了确定职业接触选定的化学品和 物理因子与术前和术后并发症的风险增加有关。 绝经后乳腺癌 一项基于人群的病例对照研究 40岁妇女绝经前后乳腺癌发病率 从1986年到1999年，在纽约州西部进行了一项研究。 1991. 只有新的、组织学证实的原发性恶性肿瘤病例 从该地区所有主要医院招募了301名乳腺癌患者 绝经前和439绝经后）。 以人口为基础的对照组 被招募，并与病例受试者的年龄和 居住的县。 由受过训练的护士进行面对面访谈- 进行了访谈，并提供了关于各种 获得可接受的和潜在的危险因素。 标准化寿命 还获得了职业史，包括详细信息 关于工作地点、职责和与之相关的活动 每一份工作。对于所有1，550名受试者，工作历史将被发送到 研究所的工业化学家和化学家专家小组 Armand-Frappier随后将向大约300名特工提供信息 使用Siemiatycki及其同事开发的方法。该团队已经 在编码这些类型的工作历史和将相当丰富的经验 与布法罗的精神病学家合作。 职业信息 工作描述中的内容足够详细，以捕捉 每个人的工作特点;因此，该系统将最大限度地减少 暴露分类错误。 统计分析，包括逻辑分析 回归和广义加法建模技术，将进行 评估职业暴露的作用，重点是 多环芳烃、特定有机溶剂和 电磁场 分析将单独进行， 绝经前和绝经后组，并在适当时合并。 确定其暴露量可修改的制剂 可能允许新的公共卫生倡议，以减少风险。 这一及时 调查应该对我们有限的 了解乳腺癌的职业危险因素。