Differentially expressed Dendritic cell surface molecules

差异表达的树突状细胞表面分子

• 批准号: nhmrc : 181609
• 负责人: A/Pr Mark Wright
• 金额: $ 32.18万
• 依托单位: Victoria University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/differentially-expressed-dendritic-surface-molecules/99910
• 关键词: Differentially; expressed; Dendritic; cell; surface

Dendritic cells are a very rare type of white blood cell which play a critical role in the initiation of the immune response. They are of particular interest to scientists interested in vaccination, as for a vaccine to work effectively, the vaccine must be presented to the rest of the immune system by the dendritic cell. It has only recently become apparent that there are several types of dendritic cell, and these different types of dendritic cell vary in their ability to present a vaccine to the immune system. We have already identified some proteins that are expressed on the surface of only one type of dendritic cell. We will explore the possible use of these proteins as a means of delivering a vaccine to only one type of dendritic cell. This project will also identify new genes that are expressed in some types of dendritic cells but not others. These new genes whose expression does differ amongst the dendritic cells are potential targets for manipulating the immune system and ensuring more efficient vaccination.

树突状细胞是一种非常罕见的白细胞类型，在免疫反应的启动中发挥着关键作用。对疫苗接种感兴趣的科学家对它们特别感兴趣，因为为了使疫苗有效发挥作用，疫苗必须由树突状细胞呈递给免疫系统的其余部分。直到最近才发现树突状细胞有多种类型，并且这些不同类型的树突状细胞向免疫系统呈递疫苗的能力各不相同。我们已经鉴定出一些仅在一种类型的树突细胞表面表达的蛋白质。我们将探索这些蛋白质作为仅向一种类型的树突细胞递送疫苗的手段的可能性。该项目还将鉴定在某些类型的树突细胞中表达但在其他类型的树突细胞中不表达的新基因。这些新基因的表达在树突状细胞中确实存在差异，是操纵免疫系统和确保更有效的疫苗接种的潜在目标。