Role of tetraspanins in integrin function and leukocyte migration

四跨膜蛋白在整合素功能和白细胞迁移中的作用

• 批准号: nhmrc : 546017
• 负责人: A/Pr Mark Wright
• 金额: $ 27.95万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-tetraspanins-integrin-leukocyte-migration/101421
• 关键词: Role; tetraspanins; integrin; function; leukocyte

Cell migration is a very important component of the immune system. White blood cells, migrate from tissues to lymph nodes to initiate immune responses, and can migrate from blood to sites of inflammation to fight infection. This grant studies a type of protein called a tetraspanin that we believe controls white blood cell migration. Understanding the precise role of tetraspanins in this process will further our understanding of inflammation in disease processes.

细胞迁移是免疫系统的一个非常重要的组成部分。白色血细胞，从组织迁移到淋巴结以启动免疫反应，并且可以从血液迁移到炎症部位以对抗感染。这项拨款研究一种叫做四跨膜蛋白的蛋白质，我们认为它控制着白色血细胞的迁移。了解四跨膜蛋白在这一过程中的确切作用将进一步了解疾病过程中的炎症。