Tetraspanins serve as molecular facilitators to regulate platelet thrombus formation

四跨膜蛋白作为调节血小板血栓形成的分子促进剂

• 批准号: nhmrc : 603812
• 负责人: A/Pr Mark Wright
• 金额: $ 39.31万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tetraspanins-serve-molecular-thrombus-formation/81563
• 关键词: Tetraspanins; serve; molecular; facilitators; regulate

Platelets are small fragments of megakaryocytes that circulate in the blood stream. They play an important role in preventing excessive blood loss at sites of tissue injury by sticking together and forming a haemostatic plug. Excessive platelet clumping in diseased blood vessels can lead to blockages and cause thrombotic diseases such as heart attack and stroke. We have discovered that tetraspanins serve to regulate platelet glycoproteins including integrin alphaIIbbeta, P2Y12 and thrombosis.

血小板是在血液中循环的巨核细胞的小碎片。它们通过粘在一起形成止血栓，在防止组织损伤部位失血过多方面发挥重要作用。病变血管中过多的血小板聚集可导致阻塞并引起血栓性疾病，如心脏病发作和中风。我们已经发现四跨蛋白可以调节血小板糖蛋白，包括整合素、P2Y12和血栓形成。