Differentiation of pro-fibrotic from anti-inflammatory effects of TGF-? in kidney fibrosis by targeting ?-catenin

TGF-β 的促纤维化作用与抗炎作用的区别？

• 批准号: nhmrc : 1046647
• 负责人: Dr Guoping Zheng
• 金额: $ 39.54万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/differentiation-pro-fibrotic-targeting-catenin/111859
• 关键词: Differentiation; pro; fibrotic; anti; inflammatory

More than 2500 Australians commence kidney replacement therapy each year and many more die of kidney failure as a result of kidney fibrosis. TGF-?, a growth factor causing kidney fibrosis, is also anti-inflammatory. Our project aims to prove that targeting a downstream messenger (?-catenin) of TGF-? will prevent kidney fibrosis while leaving TGF-?’s anti-inflammatory actions untouched. A successful outcome will lead to a novel cure for preventing kidney fibrosis and fibrosis of other organs.

每年有超过2500名澳大利亚人开始肾脏替代治疗，更多的人因肾纤维化而死于肾衰竭。TGF-？，一种导致肾纤维化的生长因子，也是抗炎的。我们的项目旨在证明，针对下游信使（？-连环蛋白）的TGF-？可以防止肾纤维化，同时留下TGF-？的抗炎作用未受影响。一个成功的结果将导致一种新的治疗方法，用于预防肾脏纤维化和其他器官的纤维化。