Preventing kidney failure using β-catenin/Foxo

使用 β-catenin/Foxo 预防肾衰竭

• 批准号: nhmrc : GNT1141235
• 负责人: Dr Guoping Zheng
• 金额: $ 86.08万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/preventing-kidney-failure-using-cateninfoxo/1348359
• 关键词: Preventing; kidney; failure; using; catenin

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is also anti-inflammatory and promotes healing. We aim to prove that targeting downstream messengers (Foxo/β-catenin) of TGF-β will prevent fibrosis while promoting TGF-β’s anti-inflammatory and healing actions. A successful outcome will lead to a novel cure for preventing kidney failure and failure of other organs.

21,000名澳大利亚人接受肾脏替代治疗，更多的人死于肾纤维化导致的肾衰竭。转化生长因子-β是一种导致肾脏纤维化的生长因子，也具有抗炎和促进愈合的作用。我们的目的是证明靶向转化生长因子-β下游信使(FOXO/β-catenin)在促进转化生长因子-βS的抗炎和愈合作用的同时，可以预防纤维化。一个成功的结果将导致一种预防肾衰竭和其他器官衰竭的新疗法。