Preventing Kidney Fibrosis By Targeting Matrix Metalloproteinase-9 In Chronic Kidney Disease

通过靶向慢性肾脏病中的基质金属蛋白酶 9 来预防肾脏纤维化

• 批准号: nhmrc : 632688
• 负责人: Dr Guoping Zheng
• 金额: $ 34.47万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/preventing-kidney-fibrosis-kidney-disease/82056
• 关键词: Preventing; Kidney; Fibrosis; Targeting; Matrix

More than 2300 Australians commence kidney replacement therapy each year and many more die of kidney failure or its complications. Kidney fibrosis is the final pathway of damage in all chronic kidney diseases. Our data demonstrates that a matrix enzyme MMP-9 is likely to be an important cause of kidney fibrosis. We aim to investigate mechanisms by which MMP-9 causes kidney fibrosis, and develop strategies involving inhibition of MMP-9 to prevent kidney fibrosis.

每年有2300多名澳大利亚人开始肾脏替代治疗，更多的人死于肾衰竭或其并发症。肾纤维化是所有慢性肾脏疾病的最终损害途径。我们的数据表明基质酶MMP-9可能是肾纤维化的一个重要原因。我们的目标是研究MMP-9导致肾纤维化的机制，并制定包括抑制MMP-9预防肾纤维化的策略。