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Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle

Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle
二亚油酰磷脂酸作为肌肉胰岛素抵抗的新型介质
批准号:
nhmrc : 481317
负责人:
A/Pr Carsten Schmitz-Peiffer
金额:
$33.61万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

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中文摘要
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英文摘要
We have identified a novel fat molecule in muscle which may play an important role in causing insulin resistance during obesity, a major factor in the development of Type 2 diabetes. We will now examine whether depletion of this molecule, dilinoleoyl-phosphatidic acid, can improve insulin action in muscles and in obese mice, and investigate the mechanisms by which it may act. This work may indicate new strategies for the treatment of diabetes.
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Action of PKC epsilon in Adipose Tissue Regulates Hepatic Glucose Production
  • 批准号:
    nhmrc : GNT1081869
  • 项目类别:
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  • 资助金额:
    $87.25万
  • 财政年份:
    2015
  • 负责人:
    A/Pr Carsten Schmitz-Peiffer
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Action of PKC epsilon in Adipose Tissue Regulates Hepatic Glucose Production
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    nhmrc : 1081869
  • 项目类别:
    Project Grants
  • 资助金额:
    $60.47万
  • 财政年份:
    2015
  • 负责人:
    A/Pr Carsten Schmitz-Peiffer
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Targeting ceramide metabolism to improve lipid-induced insulin resistance
  • 批准号:
    nhmrc : 1005819
  • 项目类别:
    NHMRC Project Grants
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    $40.3万
  • 财政年份:
    2011
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    A/Pr Carsten Schmitz-Peiffer
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The regulation of insulin action in liver and skeletal muscle by Protein kinase C epsilon
  • 批准号:
    nhmrc : 535917
  • 项目类别:
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