Action of PKC epsilon in Adipose Tissue Regulates Hepatic Glucose Production

我们以前的研究表明，蛋白激酶C epsilon(PKCE)与脂肪诱导的胰岛素抵抗的发生有关，而脂肪诱导的胰岛素抵抗是2型糖尿病的一个关键方面。与预期相反，我们现在已经证明，只有在脂肪中缺乏PKCE的动物，在喂食高脂肪饮食时，可以免受全身胰岛素抵抗的影响。该项目将研究脂肪中的PKCE通过影响其他组织，特别是肝脏的胰岛素作用，扰乱血糖水平的正常控制的机制。

Our previous studies implicated the enzyme protein kinase C epsilon (PKCe) in the development of fat-induced insulin resistance, a key aspect of Type 2 Diabetes. Contrary to expectations we have now shown that animals lacking PKCe only in fat are protected from whole body insulin resistance when fed a high-fat diet. This project will investigate the mechanisms through which PKCe in fat affects insulin action at other tissues, especially liver, to disrupt normal control of blood sugar levels.