The regulation of insulin action in liver and skeletal muscle by Protein kinase C epsilon

蛋白激酶 C epsilon 对肝脏和骨骼肌中胰岛素作用的调节

• 批准号: nhmrc : 535917
• 负责人: A/Pr Carsten Schmitz-Peiffer
• 金额: $ 43.18万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-insulin-action-c-epsilon/95173
• 关键词: regulation; insulin; action; liver; skeletal

We have identified an enzyme, protein kinase C epsilon, which has a major negative impact on the control of blood glucose levels. We will now examine the mechansisms by which it affects insulin action in liver and muscle, two major target tissues of the hormone responsible for glucose disposal. This work is expected to validate PKCepsilon or its downstream effectors as therapeutic targets in the treatment of the insulin resistance which accompanies obesity and Type 2 diabetes.

我们已经确定了一种酶，蛋白激酶C β，它对血糖水平的控制有重大的负面影响。现在我们将研究它影响肝脏和肌肉中胰岛素作用的机制，这两个组织是负责葡萄糖处理的激素的主要靶组织。这项工作有望验证PKC β或其下游效应物作为治疗肥胖和2型糖尿病伴随的胰岛素抵抗的治疗靶点。