Targeting ceramide metabolism to improve lipid-induced insulin resistance

靶向神经酰胺代谢改善脂质诱导的胰岛素抵抗

• 批准号: nhmrc : 1005819
• 负责人: A/Pr Carsten Schmitz-Peiffer
• 金额: $ 40.3万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-ceramide-metabolism-insulin-resistance/109116
• 关键词: Targeting; ceramide; metabolism; improve; lipid

We have shown that the buildup of ceramide in muscle plays a key role in the inhibition of normal insulin action when the body is exposed to excessive amounts of fat, which leads to poor control of blood sugar levels and Type 2 diabetes. Using mass spectrometry we will now measure different ceramide types, to investigate which contribute to defects in insulin action. We will also examine whether enzymes involved in ceramide formation or degradation can be targeted to improve insulin responses.

我们已经证明，当身体暴露于过量的脂肪时，肌肉中神经酰胺的积累在抑制正常胰岛素作用方面起着关键作用，这会导致血糖水平控制不良和2型糖尿病。我们现在将使用质谱法测量不同的神经酰胺类型，以研究哪些导致胰岛素作用的缺陷。我们还将研究参与神经酰胺形成或降解的酶是否可以靶向改善胰岛素反应。