Direct characterisation of naive epitope-specific T cell populations and their influence on immune responses

初始表位特异性 T 细胞群的直接表征及其对免疫反应的影响

• 批准号: nhmrc : 628316
• 负责人: Prof Nicole La Gruta
• 金额: $ 21万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/direct-characterisation-naive-immune-responses/94435
• 关键词: Direct; characterisation; naive; epitope; specific

CytotoxicT cells (CTLs) recognize and remove virus infected cells. Both the number and the diversity of T cells involved in the response influence viral clearance. We plan to use a novel technology to directly analyze the numbers and diversity of such CTLs in mice prior to infection. This will clarify how characteristics of cell populations prior to infection define the immune response after infection. This is critical for vaccine design to maximize the efficiency of the immune response.

细胞毒性T细胞（CTL）识别并清除病毒感染的细胞。参与应答的T细胞的数量和多样性都会影响病毒清除。我们计划使用一种新技术来直接分析感染前小鼠中此类CTL的数量和多样性。这将阐明感染前细胞群的特征如何定义感染后的免疫反应。这对于疫苗设计最大化免疫应答效率至关重要。