INEXPENSIVE MODULAR FLOW CY TOMETERS: A NEW GENERATION

虽然流式细胞仪已经成为生物学和医学的许多领域中研究细胞的正常和异常行为的研究人员不可或缺的，但设备的购置成本仍然很高。 激光，试剂和电子技术的最新进展，现在有可能建立多参数流式细胞仪使用廉价的二极管和固态激光源，与数字信号处理电子，它可以匹配，在某些情况下，超过现有仪器的性能的一小部分的价格。 该项目将开发和测试一种低成本流式细胞仪，并评估改善此类仪器性能的光学和电子方法。拟议的商业应用该仪器将开发一个重要的技术提供给数以百计的实验室现在无法负担它。

Although flow cytometers have become indispensable to researchers in many areas of biology and medicine who study the normal and abnormal behavior of cells, acquisition costs of apparatus remain high. Recent advances in laser, reagent and electronic technology now make it possible to build multiparameter flow cytometers using inexpensive diode and solid-state laser sources, with digital signal processing electronics, which can match, and in some cases, surpass the performance of existing instruments for a fraction of the price. This project will develop and test a low-cost flow cytometer, and evaluate optical and electronic approaches to improving performance of such instruments. PROPOSED COMMERCIAL APPLICATION The apparatus to be developed should make an important technology available to hundreds of laboratories not now able to afford it.