HERPES EYE DISEASE

疱疹眼病研究，第二阶段，是一项多机构研究 预防单纯性眼部疱疹感染。两项研究将是 阿昔洛韦与安慰剂在1)预防或 复发延迟(HEDS-APT)和2)间质的预防或延迟 上皮性角膜炎后的角膜炎或虹膜炎(HEDS-ECT)。这个 第三项研究(HEDS-RFS)是对潜在触发因素的非实验研究 眼部疱疹复发的可能性。 本申请是继续目前的HEDS协调中心 (位于加州大学旧金山分校普罗科特基金会 弗朗西斯科)作为HEDS第二阶段国家协调中心。 国家协调中心的职责将包括数据 管理、数据质量控制、统计分析和 向健康、社会和文化发展委员会提供行政和技术支持，特别是 数据和安全监测、指导和执行委员会。

The Herpetic Eye Disease Study, Phase II, is a multi-institutional study of prevention of ocular herpes simplex infections. Two studies will be randomized comparisons of acyclovir vs. placebo for 1) prevention or delay of recurrences (HEDS-APT) and 2) prevention or delay of stromal keratitis or iritis subsequent to epithelial keratitis (HEDS-EKT). The third study (HEDS-RFS) is a nonexperimental study of potential triggers of recurrence of ocular herpetic disease. This application is to continue the current HEDS Coordinating Center (located at the Proctor Foundation, University of California, San Francisco) as the National Coordinating Center for HEDS Phase II. The National Coordinating Center's responsibilities will include data management, data quality control, statistical analyses, and administrative and technical support to HEDS committees, particularly the Data and Safety Monitoring, Steering, and Executive Committees.