DEFECTS OF ACTION SPACE IN PARKINSONS DISEASE (PD)

帕金森病 (PD) 中的动作空间缺陷

• 批准号: 6187431
• 负责人: Kenneth M Heilman
• 金额: $ 13万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6187431
• 关键词: Parkinson's disease; clinical research; human subject; memory; perception disorder; proprioception /kinesthesia; psychomotor function; space perception; visual perception

DESCRIPTION: (Verbatim from the Applicant's Abstract) Spatial neglect impairs a person's ability to interact with their environment. Many of the symptoms of neglect can be induced by unilateral hemispheric injections of neurotoxins that unilaterally impair the dopaminergic systems. However, on standard test of neglect most patients with Parkinson's disease (PD) do not demonstrate neglect. PD patients most often have bilateral dopamine dysfunction and the failure to find unilateral neglect in these patients may be related to the bilaterality of this disease. There have been several reports of patients with bilateral lesions who had neglect of near or far peripersonal space. To learn if patients with PD may be neglecting far peripersonal space, we performed a pilot study. In this study we attempted to learn if the perceived size of lines or amplitude of movements were influenced by the spatial location of the stimulus in respect to the body. We found that when PD subjects perceived lines close to their body (medial) and tired to move an equal distance laterally they were hypometric. However, when they prceived a line laterally and movements centrally (medial) they were hypometric. These results suggested to us that patietns with PD may have either an abnormal perception of space, an abnormal response pattern or both. The purpose of this program is to further study Parkinson's patients spatial perceptions ad motor action sot learn if far peripersonal space is represented differently than near peripersonal space

描述：（逐字从申请人的摘要）空间忽视损害了一个 人与环境互动的能力。的许多症状 单侧大脑半球注射神经毒素可以引起忽视， 单方面损害多巴胺能系统。然而，在标准测试中， 忽视大多数帕金森病（PD）患者没有表现出忽视。 PD患者最常见的是双侧多巴胺功能障碍， 发现这些患者的单侧忽视可能与双侧性有关， 这种疾病。有几份报告称， 忽视近或远的周围空间的病变。为了了解病人是否 由于PD可能会忽略远距离的个人空间，我们进行了一项试点研究。 在这项研究中，我们试图了解，如果感知的线条大小或幅度 的运动受到空间位置的刺激， 对身体我们发现，当PD受试者感知到身体附近的线条时， （内侧）和疲劳横向移动相等的距离，他们是hypometric。 然而，当他们看到一条横向的线和中央（内侧）的运动时， 是血压过低这些结果提示PD患者可能 对空间的感知异常，反应模式异常， 两者这个项目的目的是进一步研究帕金森患者 空间感知和运动动作可以学习远距离的个人空间是否 与近个人空间不同