Smash Contrast-Enhanced 3D MR Angiography

描述(改编自申请人的摘要)：对比增强 三维磁共振血管成像(3DMRA)被证明是一种 X射线血管造影术的有用诊断辅助手段。然而，空间分辨率是 目前低于x射线血管造影术，这是原因之一 为什么磁共振血管成像还没有普遍取代X射线血管造影术。 申请人最近开发了一种增加空间和/或 在不增加渐变要求的情况下实现时间分辨率。该方法被调用 SMASH(同时获取空间谐波)和基于获取 也通过传统的相位编码同时获得空间信息 通过对来自射频线圈元件的信号进行独立采样 多线圈阵列。该方法允许加速数据采集 按与多线圈阵列中的元件数量一样大的系数进行速率。 申请人建议为CE-3DMRA开发和测试SMASH技术 临床上两个重要的血管系统：颅外颈动脉和肾 动脉。他们打算获得至少四倍的回报，并有可能达到 数据采集速度提高了8倍。加速度将会 允许在空间或时间分辨率方面进行相应改进。这个 这项建议的具体目标是：1.开发适合于 颅外颈动脉和肾动脉的成像。2.评估sMASH CE-3DMRA技术建立猪肾动脉狭窄模型。3.在 以X线血管造影术为相关金标准的患者：a) 通过提高CE-3DMRA的空间分辨率来确定SMAS是否 颅外颈动脉，提高了测量的准确性 与传统的CE-#DMRA相比，狭窄程度更低。B)确定是否可以 用于缩短肾动脉CE-3DMRA的扫描时间，而 保持与传统CE-3DMRA相同的图像质量，或 或者，通过提高肾脏的空间分辨率来看到sMash 动脉CE-3DMRA，提高了狭窄测量的准确性 常规CE-3DMRA。

DESCRIPTION (Adapted from applicant's abstract): Contrast-enhanced three-dimensional magnetic resonance angiography (3DMRA) is proving to be a useful diagnostic adjunct to x-ray angiography. However, spatial resolution is currently inferior to that afforded by x-ray angiography, which is one reason why MRA has not generally replaced x-ray angiography. The applicants have recently developed a method for increasing spatial and/or temporal resolution without increasing gradient demands. The method is called SMASH (SiMultaneous Acquisition of Spatial harmonics) and is based on obtaining spatial information simultaneously through traditional phase encoding as well as by independent sampling of signals from the radiofrequency coil elements in a multicoil array. The methodology permits an acceleration in data acquisition rate by a factor as large as the number of elements in the multicoil array. The applicants propose to develop and test the SMASH technique for CE-3DMRA in two clinically vital vascular systems: the extracranial carotid and renal arteries. They intend to obtain at least a four-fold, and potentially up to an eight-fold acceleration of the data acquisition rate. The acceleration will allow corresponding improvements in spatial or temporal resolution. The specific aims of this proposal are: 1. To develop multicoil arrays suitable for imaging of the extracranial carotid and renal arteries. 2. To evaluate SMASH CE-3DMRA using an ameroid-occluder pig model of renal artery stenosis. 3. In patients, using x-ray angiography as the correlative gold standard: a) To determine if SMAS, by improving spatial resolution of CE-3DMRA of the extracranial carotid arteries, enhances the accuracy of measurements of stenoses compared with conventional CE-#DMRA. B) To determine if SMASH can be used to reduce the scan time for CE-3DMRA of the renal arteries, while maintaining equal image quality compared with conventional CE-3DMRA, or alternatively, to see of SMASH, by improving the spatial resolution of renal artery CE-3DMRA, enhance the accuracy of measurements of stenoses compared with conventional CE-3DMRA.