The evolutionary genomics of sexual recombination

性重组的进化基因组学

• 批准号: NE/J009423/1
• 负责人: David Lunt
• 金额: $ 27.03万
• 依托单位: University of Hull
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FJ009423%2F1
• 关键词: evolutionary; genomics; sexual; recombination

The puzzling predominance of sexual reproduction amongst animals has been repeatedly identified as one of the major outstanding questions in biology and has received an enormous amount of study. Meiotic recombination is one of the fundamental forces of evolution and plays a very significant role in both generating and mixing the genetic diversity present in sexual organisms. Recombination is also suggested to be instrumental in shaping the content of eukaryotic genomes. Here we propose to study the role of breeding system and recombination in shaping the content and diversity of animal genomes using an exceptionally powerful natural system- the Root Knot Nematodes. We will, for the first time, be able to take a comparative genomic view of radically different reproductive modes in a phylogenetic design. Together these studies will give us a novel and powerful understanding of the role sexual reproduction plays in shaping genome content.

动物有性生殖的优势令人困惑，这一点一再被确认为生物学中一个主要的悬而未决的问题，并得到了大量的研究。减数分裂重组是进化的基本力量之一，在有性生物中产生和混合遗传多样性方面起着非常重要的作用。也有人建议，在塑造真核生物基因组的内容，纯化是有用的。在这里，我们建议使用一个非常强大的自然系统-根结线虫研究育种系统和重组在塑造动物基因组的内容和多样性中的作用。我们将第一次能够在系统发育设计中对完全不同的生殖模式进行比较基因组学观察。这些研究将使我们对有性生殖在塑造基因组内容中所起的作用有一个新的、强有力的理解。

项目成果

The complex hybrid origins of the root knot nematodes revealed through comparative genomics.

• DOI: 10.7717/peerj.356
• 发表时间: 2014
• 期刊: PeerJ
• 影响因子: 2.7
• 作者: Lunt DH;Kumar S;Koutsovoulos G;Blaxter ML
• 通讯作者: Blaxter ML

ReproPhylo: An Environment for Reproducible Phylogenomics.

• DOI: 10.1371/journal.pcbi.1004447
• 发表时间: 2015-09
• 期刊: PLoS computational biology
• 影响因子: 4.3
• 作者: Szitenberg A;John M;Blaxter ML;Lunt DH
• 通讯作者: Lunt DH

Genetic Drift, Not Life History or RNAi, Determine Long-Term Evolution of Transposable Elements.

• DOI: 10.1093/gbe/evw208
• 发表时间: 2016-10-05
• 期刊: Genome biology and evolution
• 影响因子: 3.3
• 作者: Szitenberg A;Cha S;Opperman CH;Bird DM;Blaxter ML;Lunt DH
• 通讯作者: Lunt DH

The evolution of tyrosine-recombinase elements in Nematoda.

• DOI: 10.1371/journal.pone.0106630
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Szitenberg A;Koutsovoulos G;Blaxter ML;Lunt DH
• 通讯作者: Lunt DH

Comparative Genomics of Apomictic Root-Knot Nematodes: Hybridization, Ploidy, and Dynamic Genome Change.

• DOI: 10.1093/gbe/evx201
• 发表时间: 2017-10-01
• 期刊: Genome biology and evolution
• 影响因子: 3.3
• 作者: Szitenberg A;Salazar-Jaramillo L;Blok VC;Laetsch DR;Joseph S;Williamson VM;Blaxter ML;Lunt DH
• 通讯作者: Lunt DH