Modularity and Metamorphosis: the effect of complex life history on cranial integration

模块化和变形：复杂的生活史对颅骨整合的影响

• 批准号: NE/J012432/1
• 负责人: Anjali Goswami
• 金额: $ 6.32万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FJ012432%2F1
• 关键词: Modularity; Metamorphosis; effect; complex; life

What drives large-scale patterns of morphological evolution? Natural selection acts upon existing variation, the raw material of evolution, to shape the diverse organisms that we see and study today, but what shapes variation? Development is often presented as a major influence on morphological variation, but linking developmental effects into large-scale models of evolution is difficult because comparative developmental data is relatively uncommon. Quantitative data, specifically measurements of the shapes of organisms and the interactions among parts of an organism, has the potential unify disparate fields of evolutionary study, from genetics to development and morphology, into a single framework. Quantification of organismal shape (morphology), during development has been hindered by difficulties in obtaining measurements from small, immature specimens, which often can lose their shape during preparation. However, in recent years, increased access to high-resolution imaging machines, such as CT scanners, and advanced visualization and digitising software has improved the possibility of gathering large volumes for rigorous statistical analyses of changes during development. The topic of morphological integration is among those that are highly quantitative and will benefit from the incorporation of comparative developmental data. These terms relate to the intuitive idea that complex organisms have many parts with varying interrelationships. Simply, a change in a foot bone would be expected to have more effect on other parts of the foot than they do on, for example, the nose. Delineating the relationships of different parts of an organism can provide novel and unpredicted information on the genetic, developmental, and functional influences on an organism's morphology, and these patterns of trait relationships are termed morphological integration. Much research on morphological integration has focused on the mammalian skull and jaws and has shown a number of interesting results. First, mammal skulls are formed of six relatively distinct regions, and this pattern of skull integration is observed across mammals, from monkeys to mice. Second, this pattern may reflect developmental interactions, such as tissue origin, as the skull is a developmentally complex structure. Third, patterns of skull integration change through development, from the early stages immediately after birth until subadulthood or adulthood. This last feature is complicated, but there is some evidence that differences in reproductive strategies, specifically between marsupials (such as kangaroos) and placentals (such as dogs or humans) are reflected in the changes in skull integration that occur during ontogeny. While most research on morphological integration in vertebrates has been conducted on mammals, especially primates and rodents, there is little comparative data on other vertebrates with which to judge whether mammalian patterns are unusual, or simply reflect a more ancestral condition. Furthermore, the diversity of developmental strategies in mammals is far less than that observed across vertebrates. In this study, we will examine morphological integration in the skull of a vertebrate with a very different developmental strategy to that seen in mammals: the African clawed frog, which undergoes metamorphosis from a larval tadpole to a froglet to an adult frog. We will use CT scanning to gather large numbers of specimens from three stages of development to test if skull integration is similar in frogs and mammals, if skull integration changes during frog development, including metamorphosis, and if skull integration in adult frogs reflects whether bones are formed before, during or after metamorphosis. The results of this study, in comparison with existing data for mammals, will form the basis for a more comprehensive study of developmental integration across tetrapods.

是什么推动了大规模的形态进化模式？自然选择作用于现有的变异，即进化的原材料，以塑造我们今天所看到和研究的各种生物体，但是是什么塑造了变异呢？发育通常被认为是形态变异的主要影响因素，但将发育效应与大规模的进化模型联系起来是困难的，因为比较发育数据相对罕见。定量数据，特别是对生物体形状和生物体各部分之间相互作用的测量，有可能将进化研究的不同领域（从遗传学到发育和形态学）统一到一个单一的框架中。在发育过程中，生物体形状（形态学）的定量一直受到难以从小的、不成熟的标本中获得测量结果的阻碍，这些标本在制备过程中往往会失去形状。然而，近年来，越来越多的高分辨率成像机器，如CT扫描仪，先进的可视化和数字化软件，提高了收集大量数据的可能性，以便对开发过程中的变化进行严格的统计分析。 形态整合的主题是那些高度定量的，将受益于比较发展数据的纳入。这些术语与复杂有机体有许多相互关系不同的部分的直观想法有关。简单地说，足部骨骼的变化预计会对足部其他部位产生更大的影响，而不是对鼻子的影响。描绘生物体不同部分之间的关系可以提供关于生物体形态的遗传、发育和功能影响的新的和不可预测的信息，这些性状关系的模式被称为形态整合。许多关于形态整合的研究都集中在哺乳动物的头骨和颌骨上，并显示了一些有趣的结果。首先，哺乳动物的头骨由六个相对不同的区域组成，从猴子到老鼠，在哺乳动物中都观察到了这种头骨整合模式。其次，这种模式可能反映了发育的相互作用，如组织起源，因为头骨是一个发育复杂的结构。第三，颅骨整合的模式在整个发育过程中发生变化，从出生后的早期阶段一直到亚成年期或成年期。这最后一个特征是复杂的，但有一些证据表明，生殖策略的差异，特别是有袋动物（如袋鼠）和胎盘动物（如狗或人类）之间的差异，反映在个体发育过程中头骨整合的变化中。 虽然大多数关于脊椎动物形态整合的研究都是在哺乳动物，特别是灵长类和啮齿类动物上进行的，但很少有关于其他脊椎动物的比较数据来判断哺乳动物的模式是否不寻常，或者只是反映了更古老的条件。此外，哺乳动物发育策略的多样性远远低于脊椎动物。在这项研究中，我们将研究形态整合的脊椎动物的头骨与一个非常不同的发展战略，在哺乳动物中看到：非洲爪蛙，它经历了从幼虫蝌蚪到幼蛙到成年青蛙的蜕变。我们将使用CT扫描从三个发育阶段收集大量标本，以测试青蛙和哺乳动物的头骨整合是否相似，青蛙发育过程中头骨整合是否发生变化，包括变态，以及成年青蛙的头骨整合是否反映了骨骼是在变态之前，期间还是之后形成的。 这项研究的结果，与现有的哺乳动物的数据相比，将形成一个更全面的研究四足动物的发展整合的基础。

项目成果

The macroevolutionary consequences of phenotypic integration: from development to deep time.

• DOI: 10.1098/rstb.2013.0254
• 发表时间: 2014-08-19
• 期刊: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• 作者: Goswami A;Smaers JB;Soligo C;Polly PD
• 通讯作者: Polly PD

An information theoretic approach to cranial modularity with 3-D morphometric data

利用 3D 形态测量数据进行颅骨模块化的信息理论方法

• 发表时间: 2014
• 作者: Goswami, A

Do Developmental Constraints and High Integration Limit the Evolution of the Marsupial Oral Apparatus?

• DOI: 10.1093/icb/icw039
• 发表时间: 2016-09
• 期刊: Integrative and comparative biology
• 影响因子: 2.6
• 作者: Goswami A;Randau M;Polly PD;Weisbecker V;Bennett CV;Hautier L;Sánchez-Villagra MR
• 通讯作者: Sánchez-Villagra MR