COMMUNITY BASED ASTHMA INTERVENTION IN PREGNANT WOMEN

对孕妇进行社区哮喘干预

• 批准号: 6178500
• 负责人: Victoria W Persky
• 金额: $ 32.5万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6178500
• 关键词: airborne allergen; asthma; behavioral /social science research tag; clinical research; community; community health services; disease /disorder prevention /control; disease /disorder proneness /risk; embryo /fetus toxicology; environmental health; female; health education; household; human birth weight; human pregnant subject; immunoglobulin E; infant human (0-1 year); longitudinal human study; passive smoking; peer group; pregnancy; respiratory disorder epidemiology; smoking; urban area

Previous studies have suggested that a variety of environmental, including in utero, exposures may affect the early development of asthma. We are currently funded for a trial to examine the effects of a peer education program designed to assess and modify the home environment of Head Start families in the West Town/Humboldt Park communities in Chicago. The purpose of the current study is to extent this program to pregnant women at risk for having asthmatic children in the same community areas. The project will build from a collaborative group already established and committed to ameliorating the course of asthma in the city of Chicago. A total of 350 pregnant women at risk for having asthmatic children will be recruited from Erie Family Health Center, Centro San Bonifacio, Emerson House, and Family Focus Nuestra Familia during the first trimester of their pregnancies over a one and a half year period. They will work with our study nurses and peer educators on assessment and modification of environmental exposures which affect the development and course of asthma, including exposure to in utero and passive smoke, pets, molds, cockroaches, and dust mites. Primary endpoints of the study will be incidence of wheezing and diagnosed asthma in the first year of life. Secondary endpoints will be birth weight of the children, percent of mothers who quit or reduce their smoking, IgE levels at one year of age, percent with positive skin tests at age one and a half years and levels of cat, cockroach, alternaria and mite antigens in the home. In addition, funds for the study will be used to strengthen our educational programs within the public and parochial schools, to increase our work with the local media, and to develop parental support groups.

以前的研究表明，各种环境， 包括在子宫内，暴露可能会影响癌症的早期发展 哮喘。我们目前正在资助一项试验，以检查这些影响 一项旨在评估和修改 西方启蒙家庭的家庭环境 芝加哥的小镇/洪堡公园社区。目的 目前的研究是将这一计划扩展到 在同一社区有哮喘儿童的风险。 该项目将建立在一个已经合作的小组 建立并致力于改善#年哮喘的病程 芝加哥这座城市。共有350名孕妇面临罹患癌症的风险 将从伊利家庭招募患有哮喘的孩子 医疗中心、圣博尼法西奥中心、爱默生之家和家庭 在他们怀孕的前三个月关注Nuestra Familia 在一年半的时间内怀孕。它们会奏效的 与我们的学习护士和同伴教育者一起进行评估和 影响环境暴露的环境暴露的修改 哮喘的发展和病程，包括宫内暴露 以及被动烟雾、宠物、霉菌、蟑螂和尘螨。 这项研究的主要终点是喘息的发生率和 在生命的第一年被诊断为哮喘。次要终端将 是孩子的出生体重、戒烟的母亲的百分比或 减少吸烟，一岁时IgE水平，百分比 一岁半的皮肤测试呈阳性，猫咪的水平， 家中的蟑螂、链格孢霉和尘螨抗原。此外, 这项研究的资金将用于加强我们的教育 在公共和教区学校内的计划，以增加我们的 与当地媒体合作，并发展父母支持小组。

项目成果

Relationship between prenatal antibiotic use and asthma in at-risk children.

• DOI: 10.1016/j.anai.2014.11.014
• 发表时间: 2015-03
• 期刊: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
• 影响因子: 5.9
• 作者: Lapin, Brittany;Piorkowski, Julie;Ownby, Dennis;Freels, Sally;Chavez, Noel;Hernandez, Eva;Wagner-Cassanova, Cynthia;Pelzel, Darlene;Vergara, Carmen;Persky, Victoria
• 通讯作者: Persky, Victoria