COMMUNITY BASED ASTHMA INTERVENTION IN PREGNANT WOMEN

对孕妇进行社区哮喘干预

• 批准号: 6077949
• 负责人: Victoria W Persky
• 金额: $ 30.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6077949
• 关键词: airborne allergen; asthma; behavioral /social science research tag; clinical research; community; community health services; disease /disorder prevention /control; disease /disorder proneness /risk; embryo /fetus toxicology; environmental health; female; health education; household; human birth weight; human pregnant subject; immunoglobulin E; infant human (0-1 year); longitudinal human study; passive smoking; peer group; pregnancy; respiratory disorder epidemiology; smoking; urban area

Previous studies have suggested that a variety of environmental, including in utero, exposures may affect the early development of asthma. We are currently funded for a trial to examine the effects of a peer education program designed to assess and modify the home environment of Head Start families in the West Town/Humboldt Park communities in Chicago. The purpose of the current study is to extent this program to pregnant women at risk for having asthmatic children in the same community areas. The project will build from a collaborative group already established and committed to ameliorating the course of asthma in the city of Chicago. A total of 350 pregnant women at risk for having asthmatic children will be recruited from Erie Family Health Center, Centro San Bonifacio, Emerson House, and Family Focus Nuestra Familia during the first trimester of their pregnancies over a one and a half year period. They will work with our study nurses and peer educators on assessment and modification of environmental exposures which affect the development and course of asthma, including exposure to in utero and passive smoke, pets, molds, cockroaches, and dust mites. Primary endpoints of the study will be incidence of wheezing and diagnosed asthma in the first year of life. Secondary endpoints will be birth weight of the children, percent of mothers who quit or reduce their smoking, IgE levels at one year of age, percent with positive skin tests at age one and a half years and levels of cat, cockroach, alternaria and mite antigens in the home. In addition, funds for the study will be used to strengthen our educational programs within the public and parochial schools, to increase our work with the local media, and to develop parental support groups.

以前的研究表明，各种环境， 包括在子宫内，暴露可能会影响 哮喘 我们目前正在进行一项试验， 一个旨在评估和修改 西方家庭的家庭环境 芝加哥的城镇/洪堡公园社区。 的目的 目前的研究是将这一方案扩大到孕妇， 在同一社区有哮喘儿童的风险。 该项目将建立从一个协作组已经 建立并致力于改善哮喘的过程， 芝加哥市。 共有350名孕妇面临 患有哮喘的儿童将从伊利家族招募 健康中心、圣博尼法乔中心、爱默生之家和家庭 关注我们的家庭在第一个三个月， 怀孕超过一年半。 他们将工作 与我们的研究护士和同伴教育者进行评估， 改变环境暴露， 哮喘的发展和病程，包括子宫内暴露于 被动吸烟、宠物、霉菌、蟑螂和尘螨。 本研究的主要终点是喘息的发生率， 在出生后的第一年被诊断为哮喘。 次要终点将 孩子的出生体重，戒烟母亲的百分比， 减少他们的吸烟，一岁时的IgE水平， 一岁半时皮肤测试呈阳性， 蟑螂、交链孢菌和螨抗原。 此外，本发明还提供了一种方法， 研究经费将用于加强我们的教育 在公立学校和教区学校的计划，以增加我们的 与当地媒体合作，并发展家长支持小组。