Peer Education in Pregnancy Study

怀孕研究中的同伴教育

• 批准号: 7013567
• 负责人: Victoria W Persky
• 金额: $ 35.71万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-18 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7013567
• 关键词: allergens; asthma; clinical research; developmental nutrition; disease /disorder etiology; disease /disorder proneness /risk; dust; early experience; endotoxins; environmental exposure; epidemiology; health education; human subject; interferon gamma; interleukin 13; interleukin 4; longitudinal human study; organophosphorus insecticide; passive smoking; peer group; pollution related respiratory disorder; pregnancy; preschool child (1-5); pyrethroid; questionnaires

DESCRIPTION (provided by applicant): The purpose of this project is to extend the investigators' previously funded Peer Education in Pregnancy Study. The overall goal of the study is to examine the effect of peer education aimed at modification of the home environment on the development of asthma in children at risk for the disease. Secondary goals are to examine the effect of environmental, psychosocial, and nutritional risk factors on the development of asthma in the overall cohort. Specific aims of this proposal are to increase the total recruitment to 500 pregnant women and their unborn infants; increase the time of follow-up of the children to age 3-5 years; expand the exposure assessment to include dust measurements of endotoxins, pyrethroids, and organophosphates and urine measurements of pesticide metabolites; extend the psychosocial and nutritional assessments to include measurements of family function stress and diet during years 1-5; and expand immune assessments to include measurements of interleukins (IL-4, IL-13, and interferon-gamma) at one year of age. The effect of peer education on the development of asthma by age 3-5, as well as the effect of peer education on intermediary endpoints such as smoking, exposure to indoor allergens (cat, cockroach, mite, mouse, beta-glucan, and endotoxins), exposure to pesticides (pyrethroids and organophosphates), and immune function (IgE levels, skin testing for allergens, and cytokines) will be examined. Relationships of exposure to passive smoke, allergens, and pesticides, as well as measures of psychosocial function and nutrition, with the development of asthma and respiratory symptoms in the overall cohort will also be explored. Results of this study will assist in elucidating the etiologic pathway by which asthma develops early in life, as well as assist in the development of effective intervention programs.

描述（由申请人提供）： 该项目的目的是扩大研究人员先前资助的 妊娠研究中的同伴教育。 研究的总体目标是 检查旨在改造家庭的同伴教育的效果 环境对有患病风险的儿童患哮喘的影响。 次要目标是检查环境、心理社会和 影响整个队列中哮喘发生的营养危险因素。 该提案的具体目标是将招募总数增加到 500 人 孕妇及其未出生的婴儿；增加跟进时间 3-5岁儿童；扩大暴露评估范围以包括灰尘 内毒素、拟除虫菊酯、有机磷酸酯和尿液的测量 农药代谢物的测量；扩展心理社会和营养 评估包括测量家庭功能、压力和饮食 1-5 年；并扩大免疫评估范围，包括测量 一岁时注射白细胞介素（IL-4、IL-13 和干扰素-γ）。 这 同伴教育对 3-5 岁哮喘发展的影响，以及 同伴教育对吸烟等中间终点的影响， 接触室内过敏原（猫、蟑螂、螨虫、老鼠、β-葡聚糖和 内毒素）、接触农药（拟除虫菊酯和有机磷酸酯），以及 免疫功能（IgE 水平、过敏原皮肤测试和细胞因子）将 被检查。 暴露于被动吸烟、过敏原和 杀虫剂以及心理社会功能和营养的测量， 整个队列中哮喘和呼吸道症状的发展将 也有待探讨。 这项研究的结果将有助于阐明 哮喘在生命早期发生的病因学途径，以及协助 制定有效的干预计划。