SERUM HORMONES IN VEGETARIAN AND NON-VEGETARIAN GIRLS

有大量的流行病学和实验证据表明，饮食 影响乳腺癌的风险。 据推测，饮食因素 通过荷尔蒙环境的改变，特别是在青少年时期， 当乳房被认为是特别敏感， 致癌物质。 先前关于女性激素水平的跨文化研究 不同的饮食产生了不确定的结果。 然而，这些研究， 集中在血清总雌激素和雄激素的比较。 的 拟议的研究将检查未结合和白蛋白结合血清的水平 雌二醇和睾酮，以及排卵状态，在两组 青春期后的少女 一组由110所寄宿学校组成 基督复临安息日会教徒谁摄取乳蛋素食饮食;其他 该组织由125名非素食女孩组成，她们在另一所寄宿学校学习， 芝加哥地区。 饮食摄入量将记录在7天的食物中 记录和测量下列激素：总， 白蛋白结合和游离雌二醇 睾丸激素;和类固醇结合性激素结合球蛋白， 一个月经周期的第10或11天和第22或23天。 排卵状态 将从第22或23天的血清孕酮和两次尿中测定 孕二醇样本之间的第20和24天，从每个六个周期。 还将对可能的混杂变量进行测量，例如 初潮年龄，初潮后时间，药物使用，身高，体重， 皮褶厚度和身体健康水平。 除了组 比较，分析将在每组女孩中进行 检查每种激素水平和饮食之间的关系， 影响乳腺癌风险的变量。 如果发现激素水平存在显著的组间差异， 拟议研究的结果将作为干预措施的基础 在一所寄宿学校进行的一项试验， 荷尔蒙平衡

There exists substantial epidemiologic and experimental evidence that diet affects risk of breast cancer. It has been postulated that dietary factors act through alterations in the hormonal milieu, especially in the teenage years when the breast is thought to be particularly sensitive to carcinogens. Previous cross-cultural studies of hormone levels in women on different diets have yielded inconclusive results. Those studies, however, have focused on comparisons of total serum estrogens and androgens. The proposed study will examine levels of unbound and albumin-bound serum estradiol and testosterone, as well as ovulatory status, in two groups of postmenarchial teenage girls. One group is composed of 110 boarding school Seventh-Day Adventists who ingest lacto-ovo-vegetarian diets; the other group is composed of 125 non-vegetarian girls in another boarding school in the Chicago area. Dietary intake will be documented with seven-day food records and measurements will be made of the following hormones: total, albumin-bound and free estradiol; total, albumin-bound and free testosterone; and steroids bound to sex-hormone-binding globulin on both day 10 or 11 and day 22 or 23 of one menstrual cycle. Ovulatory status will be determined from one day 22 or 23 serum progesterone and two urine pregnandiol specimens between days 20 and 24 from each of six cycles. Measurements will also be made of possible confounding variables such as age at menarche, time since menarche, medication use, height, weight, skinfold thickness, and physical fitness level. In addition to group comparisons, analyses will be performed within each group of girls examining the relationships between each hormone level and dietary variables which have been implicated as affecting risk of breast cancer. Should significant group differences in hormone levels be found, the results of the proposed study will be used as the basis of an intervention trial at one of the boarding schools to study the effect of dietary change on hormonal balance.