CORE--NEUROPATHOLOGY

神经病理学核心的总体目标是通过向研究者提供AD患者和正常老年对照受试者的经过彻底评估的脑标本，支持和刺激对AD和年龄相关痴呆症的研究。神经病理学核心的具体目标是使用我们的快速尸检团队，使用标准化方案对AD和其他年龄相关痴呆症患者以及认知正常的老年人进行短期尸检，纵向跟踪对照受试者。核心将保持一个银行的脑标本，脑脊液和突触体准备从我们的短期PMI尸检的主题。核心将提供尸检诊断、神经系统缠结、六个脑区的神经炎和弥漫性斑块定量以及多个脑区突触素的狭缝印迹免疫化学分析，供研究者使用。它将与临床核心相关联的临床，神经心理学和神经病理学特征的痴呆症和对照组，并将评估的有效性和有效性的神经病理学指南诊断AD的国家老龄化研究所里根研究所工作组。神经病理学核心将强调我们纵向跟踪的正常老年对照组，特别是轻度认知障碍和早期AD患者大脑中存在的变化。重点也将放在抗痴呆症受试者的脑储备的形态学基础上。将从海马和内嗅皮质制备用于无偏体视学方法的标本，供研究者使用。该核心支持两个英国AD计划项目赠款，几个R 01 AD相关赠款，和两个纵向神经流行病学研究，NUN研究和檀香山-亚洲老龄化研究，两者都有尸检终点。

The overall objective of the Neuropathology Core is to support and stimulate research on AD and age-related dementing disorders by supplying thoroughly evaluated brain specimens from AD patients and normal aged control subjects to investigators. The specific aims of the Neuropathology Core are to use our Rapid Autopsy Team to perform short postmortem interval PMI autopsies using a standardized protocol on longitudinally followed patients with AD and other age-related dementing disorders and cognitively normal aged, longitudinally followed, control subjects. The core will maintain a bank of brain specimens cerebrospinal fluid and synaptosome preparations from our short PMI autopsied subjects. The core will provide postmortem diagnosis, neurofibrillary tangle, neuritic and diffuse plaque quantification in six brain regions and slot-blot immunochemistry analysis of synaptophysin in multiple brain regions for investigator use. It will correlate the clinical, neuropsychological and neuropathological features of demented and control subjects in conjunction with the Clinical Core and will evaluate the effectiveness and validity of the neuropathological guidelines for the diagnosis of AD developed by the National Institute of Aging-Reagan Institute Working Group. The Neuropathology Core will emphasize the alterations present in the brain in our longitudinally followed normal aged control group, especially those with Mild Cognitive Impairment and early AD. Emphasis also will be placed on the morphological substrate of brain reserve in subjects resistant to dementia. Specimens for the unbiased stereological method will be prepared from the hippocampus and entorhinal cortex for investigator use. The core supports two UK AD program project grants, several R01 AD related grants, and two longitudinal neuroepidemiologic studies, the NUN Study and the Honolulu-Asian Aging Study, both with autopsy end points.