ALZHEIMER'S DISEASE CORE CENTER

描述（由申请人提供）：这是肯塔基州大学桑德斯-布朗老龄中心5年阿尔茨海默病核心中心（ADCC）的申请。该应用程序包括临床，生物统计和数据管理，神经病理学，教育和信息传输核心。英国ADC在AD的临床，神经病理学，教育和研究方面开发了一个强大的计划，在过去的二十年中，该计划作为大学，社区，州和地区的资源。英国ADC的主要目标是：a）向英国的AD和衰老研究者以及国内和国际研究者提供来自彻底评估的、纵向随访的正常对照受试者、AD和非AD痴呆症受试者的临床数据、血清、血浆、血沉棕黄层和CSF，以及来自这些受试者的尸检材料，B）继续症状前AD、轻度认知障碍、早期AD的纵向研究，混合型痴呆和其他痴呆，以及正常的脑老化，尸检作为终点; c）开发新的研究计划，吸引新的研究人员研究神经退行性变和衰老; d）强调服务少数民族，让他们参与研究;和e）参与多中心的努力，包括NACC，ADCS，ADNI等。临床核心将评估和纵向跟踪正常对照（BRAINS）诊所的500名受试者和痴呆症研究诊所的200名AD和其他痴呆症患者-所有患者都有预先安排的尸检。该核心将在北列克星敦为非裔美国人维持一个卫星诊所，同时提供老龄化管理局赠款，用于教育少数民族了解痴呆症。神经病理学核心为研究者提供了来自纵向跟踪的正常、MCI、早期和晚期AD患者以及非AD痴呆患者的短死后间隔脑标本、CSF和突触体，并维护了组织库。生物统计和数据管理核心管理来自其他核心的数据集，准备统一数据集和最小数据集以提交给NACC，并提供统计设计和分析。教育和信息传输核心协助招募控制和痴呆症受试者，为研究人员和医疗保健专业人员提供研究和临床培训，并向公众传播信息。

DESCRIPTION (provided by applicant): This is an application for a 5-year Alzheimer's Disease Core Center (ADCC) at the University of Kentucky's Sanders-Brown Center on Aging. The application consists of the Clinical, Biostatistics and Data Management, Neuropathology, Education and Information Transfer Cores. The UK ADC has developed a strong program in the clinical, neuropathological, educational and research aspects of AD that serves as a resource for the university, community, state, and region for the past twenty years. The major goals of the UK ADC are to: a) provide clinical data, serum, plasma, buffy coats and CSF from thoroughly evaluated, longitudinally followed, normal control subjects, AD and non-AD dementing disorders, and postmortem material from these subjects to investigators of AD and aging at UK and to national and international investigators, b) continue longitudinal investigation of presymptomatic AD, mild cognitive impairment, early AD, mixed dementias and other dementias, and normal brain aging with autopsy as an end point; c) develop new research initiatives and attract new investigators to research in neurodegeneration and aging; d) place emphasis on serving minorities and involving them in research; and e) participate in multicenter efforts, including NACC, ADCS, ADNI, and others. The Clinical Core will evaluate and longitudinally follow 500 subjects in the Normal Control (BRAINS) Clinic and 200 patients with AD and other dementias in the Dementia Research Clinic - all with prearranged autopsies. This core will maintain a satellite clinic for African Americans in north Lexington in conjunction with an Administration on Aging grant for education of minorities about dementing disorders. The Neuropathology Core provides short postmortem interval brain specimens, CSF, and synaptosomes from longitudinally followed normal, MCI, early and late AD patients, and non-AD dementias to investigators and maintains a tissue bank. The Biostatistics and Data Management Core manages data sets from the other Cores, prepares the Uniform Data Set and the Minimum Data Set for submission to the NACC, and provides statistical design and analysis. The Education and Information Transfer Core assists with recruiting control and dementia subjects, provides research and clinical training for investigators and healthcare professionals, and disseminates information to the lay public.