ALZHEIMER'S DISEASE CORE CENTER

描述（由申请人提供）：这是肯塔基大学桑德斯-布朗老龄化中心5年阿尔茨海默病核心中心（ADCC）的申请。该应用程序由临床、生物统计学和数据管理、神经病理学、教育和信息传递核心组成。在过去的二十年里，英国ADC在阿尔茨海默病的临床、神经病理、教育和研究方面制定了一个强大的计划，作为大学、社区、州和地区的资源。英国艺发局的主要目标是：a)提供临床数据、血清、血浆、灰褐色皮毛和脑脊液从彻底评估，纵向跟踪，正常对照，阿尔茨海默病和非阿尔茨海默病痴呆，并从这些对象的死后材料的阿尔茨海默病和衰老研究者在英国和国内和国际；b)继续纵向调查症状前阿尔茨海默病，轻度认知障碍，早期阿尔茨海默病，混合性痴呆和其他痴呆，和正常脑老化以尸检为终点；C)发展新的研究计划，吸引新的研究者来研究神经变性和衰老；D)强调为少数民族服务并让他们参与研究；e)参与多中心工作，包括NACC、ADCS、ADNI等。临床核心将评估和纵向跟踪正常对照（BRAINS）诊所的500名受试者和痴呆症研究诊所的200名AD和其他痴呆症患者-所有这些都是预先安排的尸检。该中心将为北列克星敦的非裔美国人维持一个卫星诊所，并与老龄化管理局一起为少数民族提供有关痴呆症的教育。神经病理学中心为研究人员提供了纵向随访的正常、轻度认知损伤、早期和晚期AD患者以及非AD痴呆患者的短死间隔脑标本、CSF和突触体，并维持了一个组织库。生物统计和数据管理核心负责管理来自其他核心的数据集，准备提交给NACC的统一数据集和最小数据集，并提供统计设计和分析。教育和信息传递核心协助招募控制和痴呆症受试者，为调查人员和保健专业人员提供研究和临床培训，并向普通公众传播信息。

DESCRIPTION (provided by applicant): This is an application for a 5-year Alzheimer's Disease Core Center (ADCC) at the University of Kentucky's Sanders-Brown Center on Aging. The application consists of the Clinical, Biostatistics and Data Management, Neuropathology, Education and Information Transfer Cores. The UK ADC has developed a strong program in the clinical, neuropathological, educational and research aspects of AD that serves as a resource for the university, community, state, and region for the past twenty years. The major goals of the UK ADC are to: a) provide clinical data, serum, plasma, buffy coats and CSF from thoroughly evaluated, longitudinally followed, normal control subjects, AD and non-AD dementing disorders, and postmortem material from these subjects to investigators of AD and aging at UK and to national and international investigators, b) continue longitudinal investigation of presymptomatic AD, mild cognitive impairment, early AD, mixed dementias and other dementias, and normal brain aging with autopsy as an end point; c) develop new research initiatives and attract new investigators to research in neurodegeneration and aging; d) place emphasis on serving minorities and involving them in research; and e) participate in multicenter efforts, including NACC, ADCS, ADNI, and others. The Clinical Core will evaluate and longitudinally follow 500 subjects in the Normal Control (BRAINS) Clinic and 200 patients with AD and other dementias in the Dementia Research Clinic - all with prearranged autopsies. This core will maintain a satellite clinic for African Americans in north Lexington in conjunction with an Administration on Aging grant for education of minorities about dementing disorders. The Neuropathology Core provides short postmortem interval brain specimens, CSF, and synaptosomes from longitudinally followed normal, MCI, early and late AD patients, and non-AD dementias to investigators and maintains a tissue bank. The Biostatistics and Data Management Core manages data sets from the other Cores, prepares the Uniform Data Set and the Minimum Data Set for submission to the NACC, and provides statistical design and analysis. The Education and Information Transfer Core assists with recruiting control and dementia subjects, provides research and clinical training for investigators and healthcare professionals, and disseminates information to the lay public.