ALZHEIMER'S DISEASE CORE CENTER

描述(申请人提供)：这是肯塔基大学桑德斯-布朗老龄中心(ADCC)为期5年的阿尔茨海默病核心中心(ADCC)的申请。该应用程序由临床、生物统计和数据管理、神经病理学、教育和信息传输核心组成。在过去的二十年里，英国ADC在AD的临床、神经病理、教育和研究方面发展了一项强大的计划，作为大学、社区、州和地区的资源。英国ADC的主要目标是：a)向英国的AD和老龄化研究人员以及国内和国际调查人员提供来自彻底评估的、纵向跟踪的正常对照受试者、AD和非AD痴呆症受试者的临床数据、血清、血浆、棕黄色外衣和脑脊液，以及这些受试者的尸检材料；b)继续对症状前AD、轻度认知障碍、早期AD、混合性痴呆和其他痴呆症以及以尸检为终点的正常脑老化进行纵向调查；c)开发新的研究计划，吸引新的研究人员参与神经变性和衰老的研究；d)强调为少数族裔服务并让他们参与研究；以及e)参与多中心的努力，包括NACC、ADCS、ADNI等。临床核心将评估和纵向跟踪正常对照(大脑)诊所的500名受试者和痴呆症研究诊所的200名AD和其他痴呆症患者-所有人都有预先安排的尸检。该核心将与老龄管理局合作，在列克星敦北部为非裔美国人维持一家卫星诊所，为少数族裔提供有关痴呆障碍的教育。神经病理学中心为研究人员提供了短时间的死后脑组织标本、脑脊液和突触体，这些标本来自于纵向追踪的正常人、MCI、早期和晚期AD患者以及非AD痴呆患者，并维持着一个组织库。生物统计和数据管理核心管理来自其他核心的数据集，准备统一的数据集和最小数据集以提交给国家统计中心，并提供统计设计和分析。教育和信息传输核心协助招募控制和痴呆症受试者，为调查人员和医疗保健专业人员提供研究和临床培训，并向非专业公众传播信息。

DESCRIPTION (provided by applicant): This is an application for a 5-year Alzheimer's Disease Core Center (ADCC) at the University of Kentucky's Sanders-Brown Center on Aging. The application consists of the Clinical, Biostatistics and Data Management, Neuropathology, Education and Information Transfer Cores. The UK ADC has developed a strong program in the clinical, neuropathological, educational and research aspects of AD that serves as a resource for the university, community, state, and region for the past twenty years. The major goals of the UK ADC are to: a) provide clinical data, serum, plasma, buffy coats and CSF from thoroughly evaluated, longitudinally followed, normal control subjects, AD and non-AD dementing disorders, and postmortem material from these subjects to investigators of AD and aging at UK and to national and international investigators, b) continue longitudinal investigation of presymptomatic AD, mild cognitive impairment, early AD, mixed dementias and other dementias, and normal brain aging with autopsy as an end point; c) develop new research initiatives and attract new investigators to research in neurodegeneration and aging; d) place emphasis on serving minorities and involving them in research; and e) participate in multicenter efforts, including NACC, ADCS, ADNI, and others. The Clinical Core will evaluate and longitudinally follow 500 subjects in the Normal Control (BRAINS) Clinic and 200 patients with AD and other dementias in the Dementia Research Clinic - all with prearranged autopsies. This core will maintain a satellite clinic for African Americans in north Lexington in conjunction with an Administration on Aging grant for education of minorities about dementing disorders. The Neuropathology Core provides short postmortem interval brain specimens, CSF, and synaptosomes from longitudinally followed normal, MCI, early and late AD patients, and non-AD dementias to investigators and maintains a tissue bank. The Biostatistics and Data Management Core manages data sets from the other Cores, prepares the Uniform Data Set and the Minimum Data Set for submission to the NACC, and provides statistical design and analysis. The Education and Information Transfer Core assists with recruiting control and dementia subjects, provides research and clinical training for investigators and healthcare professionals, and disseminates information to the lay public.