BIOCHEMICAL, MORPHOLOGICAL, AND TRACE ELEMENT STUDIES IN ALZHEIMER'S DISESAE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定是研究者机构。阿尔茨海默病研究中心临床核心的目的是提供临床数据，研究参与者和获得尸检材料的方法。它旨在帮助研究AD和相关疾病的当前核心科学问题。临床核心并不直接解决这些问题，但提供了一组特征良好的主题，使这些重要的当前问题的实质性研究。为了做到这一点，临床核心1）遵循一组社区居住的正常老年人进行尸检，2）遵循现有的一组痴呆症患者进行尸检，3）评估和诊断患有记忆障碍的个体，以及4）添加到研究中潜在参与者的个体登记册中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of the Alzheimer's Disease Research Center Clinical Core is to provide clinical data, study participants and the means of obtaining autopsy materials for research. It is designed to aid research on current central scientific questions in AD and related diseases. The clinical core does not address these questions directly, but makes available a group of well-characterized subjects to enable substantive research on these important current questions. To do this, the clinical core 1) follows a group of community-dwelling normal elderly individuals to autopsy, 2) follows an existing group of individuals with dementia to autopsy, 3) evaluates and diagnoses individuals with memory disorders, and 4) adds to the registry of individuals who are potential participants in research studies.