CORE--CLINICAL

临床核心的总体目标是招募、评估和 跟踪阿尔茨海默病(AD)患者，与痴呆症相关 和正常对照，为临床提供具有良好特征的受试者 研究项目和随后的病理学研究。具体目标 A)招聘、评估和有系统地纵向跟踪 患有阿尔茨海默病和相关痴呆的患者，b)招募和 评估一系列认知正常的社区住宅(N=400)或 养老院(N=50)同意的志愿者对照受试者 预先安排的尸检，c)提供系统的纵向跟踪 认知功能(每年)和神经学发现(每隔一年) 对照受试者，d)保持临床、神经心理学和 关于阿尔茨海默病、相关痴呆障碍和控制的行为数据库 受试者，e)增加AD患者的尸检和 然后调查神经学、神经心理学和 行为学发现与定量组织病理学和 尸检发现的区域变化，f)继续参与 多中心治疗药物试验，g)继续参与 联盟项目，包括AD合作研究和CERAD，h)至 增加阿尔茨海默病和相关障碍患者的数量(少数民族和 农村)在我们的卫星诊断和治疗诊所，i)注册 少数民族和农村控制对象通过我们的卫星诊断和 治疗诊所。 我们目前在我们的记忆障碍诊所跟踪调查了500名患者。我们有 招募了317名认知正常的志愿者对照组受试者，他们都是 都同意在死后捐献大脑。

The overall objective of the Clinical Core is to recruit, evaluate and follow patients with Alzheimer's disease (AD), related dementing disorders and normal controls to provide well-characterized subjects for clinical research projects and subsequent pathologic studies. The specific aims are a) to recruit, evaluate and systematically longitudinally follow patients with AD and related dementing disorders, b) to recruit and evaluate a series of cognitively normal community-dwelling (N=400) or nursing home (N=50) volunteer control subjects who have consented to prearranged autopsy, c) to provide a systematic longitudinal follow-up of cognitive function (annual) and neurologic findings (every other year) of control subject, d) to maintain a clinical, neuropsychologic and behavioral database on AD, related dementing disorders, and control subjects, e) to increase the number of AD patients who come to autopsy and then investigate associations between neurologic, neuropsychologic, and behavioral findings as they relate to quantitative histopathologic and regional changes found at autopsy, f) to continue participation in multicenter therapeutic drug trial, g) to continue participation in consortium projects including the AD Cooperative Studies and CERAD, h) to increase the number of AD and related disorders patients (minority and rural) in our Satellite Diagnostic and Treatment Clinics, and i) to enroll minority and rural control subjects through our Satellite Diagnostic and Treatment Clinics. We presently follow 500 patients in our Memory Disorders Clinic. We have recruited 317 cognitively normal volunteer control subjects, all of whom have consented to brain donation at death.