A mechanistic approach to therapy development for chronic traumatic encephalopathy using small and large animal models of concussion

使用小型和大型脑震荡动物模型开发慢性创伤性脑病治疗的机械方法

• 批准号: nhmrc : 1068712
• 负责人: A/Pr Renee Turner
• 金额: $ 32.86万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanistic-approach-therapy-models-concussion/455354
• 关键词: mechanistic; approach; therapy; development; chronic

Repeated concussion in athletes has recently been associated with the development of a neurodegenerative disorder known as chronic traumatic encephalopathy (CTE). While the neuropathology seems to be well characterised, the mechanisms associated with CTE development are not. This proposal will demonstrate that mechanically induced release of the neurotransmitter substance P accounts for much of the neuropathology in CTE, and will develop a novel therapy that will prevent such development.

运动员的反复脑震荡最近与一种称为慢性创伤性脑病（CTE）的神经退行性疾病的发展有关。虽然神经病理学似乎很好地表征，但与CTE发展相关的机制还没有。该提案将证明，机械诱导的神经递质物质P的释放占CTE中神经病理学的大部分，并将开发一种新的治疗方法，将防止这种发展。