Improving clinical translation in stroke: targeting cerebral oedema in a large animal model

改善中风的临床转化：针对大型动物模型中的脑水肿

• 批准号: nhmrc : GNT1082556
• 负责人: A/Pr Renee Turner
• 金额: $ 61.72万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-clinical-translation-animal-model/1345468
• 关键词: Improving; clinical; translation; stroke; targeting

A common and life-threatening complication of stroke is brain swelling which is the leading cause of death within one week of stroke and a predictor of poor outcome. Current treatments for brain swelling are inadequate. We have developed a drug that blocks the action of the neuropeptide substance P, which is involved in the development of swelling. We will assess the efficacy of this treatment to reduce brain swelling and improve long-term outcome in a relevant pre-clinical model of stroke.

脑肿胀是中风常见且危及生命的并发症，它是中风后一周内死亡的主要原因，也是预后不良的预测指标。目前治疗脑肿胀的方法还不充分。我们已经开发出一种药物，可以阻止神经肽P物质的作用，这种物质与肿胀的形成有关。我们将在卒中的相关临床前模型中评估这种治疗在减少脑肿胀和改善长期预后方面的疗效。