MECHANICAL ORGINS OF SHOCK INDUCED BIOEFFECTS IN SHOCK WAVE LITHOTRIPSY

冲击波碎石术中冲击引起的生物效应的机械根源

• 批准号: 6105482
• 负责人: BRADFORD STURTEVANT
• 金额: $ 16.12万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6105482
• 关键词: bioengineering /biomedical engineering; biomechanics; biomedical equipment development; cellular pathology; clinical biomedical equipment; iatrogenic disease; kidney disorder; kidney function; lithotripsy; mathematical model; mechanical pressure; mechanical stress; model design /development; nephrolithiasis; phantom model; tissue /cell culture; ultrasound biological effect

This grant is the continuation of a collaborative multi-disciplinary study of the mechanical initiation of injury to soft tissue in the kidney and of damage to tissue analogs by ESWL shock waves. Experiments are carried out in a laboratory lithotripter of our own design that mimics the Dornier HM3 electrohydraulic lithotripter. Finite-difference numerical solutions of the Euler equations are obtained for focusing shock waves interacting with tissue and kidney stones. Cooperative research is carried out with the other Projects of this Program Project Grant to advance the objectives of the Grant. The aims of this Project are: I. Extend the dose criterion developed in our previous work on the cavitation-free failure of planar membranes to more complex weak mechanical structures and, in collaboration with Project 2, to in vitro cell cultures. Included in this aim is the development of a tissue phantom which reliably mimics the shock-wave scattering properties of soft tissue, development PVDF transducer arrays, investigation of membrane material/cavitation-free host fluid combinations and thin-membrane cylindrical structures for damage studies, and collaborations with Projects 1 and 2 to develop a physically-based quantitative definition of ESWL dose. II. Initiate a new effort in Project 4 to demonstrate the mechanisms of kidney stone comminution by ESWL. Included in this aim is utilization of the Hopkinson bar technique to characterize the failure dynamics of real and phantom calculi, and development of a stone phantom which faithfully mimics the failure models of kidney stones. III. Develop numerical methods for solving the exact Euler equations of motion. Included in this aim is adaptation of the Amrita problem-solving environment to shock wave focusing problems, calculation of shock wave focusing by an ellipse in uniform and non-uniform media, and calculation of wave shapes and compressive stresses induced by impingement of a shock wave on a theoretical calculus. The hypothesis that the above aims are designed to test include: 1. A quantitative definition of ESWL dose, based on the physical properties of waves and tissue, can be developed to quantify the mechanical input of ESWL to tissue. 2. Comminution of kidney stones in ESWL occurs under shock compression by dynamic fatigue. 3. Accurate numerical calculations of shock pressure and wave geometry during shock wave focusing can be used with experimental data to elucidate mechanisms of stone comminution and tissue injury.

这笔赠款是一项多学科合作研究的延续。 对肾脏软组织的机械性损伤和 ESWL冲击波对组织类似物的损害。进行了实验。 在我们自己设计的模仿Dornier HM3的实验室碎石机中 电液压碎石机。方程的有限差分数值解 得到了聚焦激波与激波相互作用的欧拉方程。 组织和肾结石。合作研究是与 本计划的其他项目项目赠款，以促进以下目标 格兰特。这项计划的目标是： I.扩展我们在以前关于 平面膜对更复杂弱结构的无空化破坏 机械结构，并与项目2合作，在体外 细胞培养。该目标包括开发一种组织体模 其可靠地模拟软组织的冲击波散射特性， 聚偏氟乙烯换能器阵列的研制、膜的研究 材料/无空化主体流体组合和薄膜 用于损伤研究的圆柱形结构，以及与 项目1和2，以制定基于物理的量化定义 ESWL剂量。 在项目4中发起一项新的努力，以演示 体外冲击波碎石治疗肾结石。这一目标包括利用 用Hopkinson杆技术表征复合材料的破坏动力学 和幽灵结石，并开发了一种忠实于 模拟肾结石的衰竭模型。 发展了精确求解欧拉方程的数值方法 动议。这一目标包括对解决问题的AMRITA的改编 环境对冲击波聚焦问题，冲击波计算 椭圆在均匀和非均匀介质中的聚焦及计算 冲击波冲击产生的波形和压应力 在一个理论微积分上挥手。 上述目标旨在测试的假设包括： 1.ESWL剂量的定量定义，基于物理 波和组织的特性，可以被开发来量化 体外冲击波碎石对组织的机械输入。 2.体外冲击波碎石术中肾结石在冲击波作用下发生粉碎。 动态疲劳。 3.冲击波压力和波几何的精确数值计算 在激波聚焦过程中可以用实验数据来说明 结石粉碎和组织损伤的机制。