PERIPHERAL SENSORY SYSTEM DEVELOPMENT AND REGENERATION

外周感觉受体的发育和再生涉及动态的生物学过程，其中祖细胞最终形成能够传导环境刺激的成熟功能受体。这些过程包括诱导增殖和分化、迁移到适当的目的地、结构和功能的成熟、细胞周期的维持以及与适当的神经单位的连接。虽然这些过程在感觉系统之间是共享的，但重要的特征对于每个系统来说都是独一无二的。通过对发育和再生系统之间的共性和差异的协调研究，将有可能提供组织原则，使我们能够理解周围感觉细胞的发育和感觉细胞对损伤的再生反应。因此，该计划项目拨款（PPG）的长期目标是研究相关感觉系统中感觉受体细胞发育和再生过程中的常见和独特过程。具体来说，我们将研究嗅觉、听觉和味觉受体细胞的发育和再生。PPG分为三个主要的综合项目，这些项目利用了该计划下属调查人员的专业知识和协作努力。在项目1中，将研究嗅觉和听觉相关结构的早期胚胎诱导。项目2和项目3分别研究哺乳动物听觉毛细胞和味觉受体细胞的功能和形态再生，以及免疫系统在这些感觉受体再生中的作用。虽然具有相同感觉系统（如听觉系统）和相同实验重点（如开发或再生）的项目之间存在明显的共性，但所有项目之间都存在重大的科学和技术重叠。因此，本提案中详细的实验共同形成了一个多学科的研究项目，非常适合于研究外围感觉系统发育和再生的基本和及时的问题。

The development and regeneration of peripheral sensory receptors involve dynamic biological processes in which progenitor cells ultimately form mature, functional receptors capable of transducing environmental stimuli. Such processes include induction7 proliferation and differentiation, migration to the proper destinations, structural and functional maturation, maintenance of the cell cycle, and connections with the proper neural units. While these processes-are shared among sensory systems, important characteristics are unique to each Through a coordinated study of the commonalities and differences among the developing and regenerating systems, it will be possible to provide organizing principles that allow an understanding of peripheral sensory cell development and of sensory cell regeneration in response to injury. Thus, the long term goal of this Program Project Grant (PPG) is to examine common and unique processes during development and regeneration o sensory receptor cells in related sensory systems. Specifically, we will study olfactory, auditory, and gustatory receptor cell development and regeneration. The PPG is divided into three main, integrated projects that exploit the expertise and collaborative efforts of the investigators affiliated with the Program. In Project 1 the early embryonic induction of olfactory- and auditory-related structures will be studied. Projects 2 and 3 involve studies of the functional and morphological regeneration of mammalian auditory hair cells and gustatory receptor cells, respectively, and the role of the immune system in the regeneration of these sensory receptors. While clear commonalities exist among projects that share the same sensory system (e.g., auditory system) and the same experimental focus (e.g., development or regeneration), significant scientific and technical overlap is present among all projects. Therefore, experiments detailed in this proposal collectively form a program of study that is multidisciplinary in nature and ideally suited to investigate fundamental and timely issues common to peripheral sensory system development and regeneration.