PERIPHERAL SENSORY SYSTEM DEVELOPMENT & REGENERATION

外周感觉受体的发育和再生涉及动态生物过程，其中祖细胞最终形成能够转导环境刺激的成熟的功能性受体。这些过程包括诱导增殖和分化、迁移到适当的目的地、结构和功能成熟、细胞周期的维持以及与适当的神经单元的连接。虽然这些过程是共享的感觉系统，重要的特征是独一无二的，通过协调的共同点和发展和再生系统之间的差异研究，它将有可能提供组织的原则，允许理解外周感觉细胞的发展和感觉细胞再生的损伤。因此，本计划项目资助（PPG）的长期目标是研究相关感觉系统中感觉受体细胞发育和再生过程中的共同和独特过程。具体来说，我们将研究嗅觉，听觉和味觉受体细胞的发育和再生。PPG分为三个主要的综合项目，利用与该计划有关的调查人员的专业知识和协作努力。在项目1中，将研究嗅觉和听觉相关结构的早期胚胎诱导。项目2和3分别涉及哺乳动物听觉毛细胞和味觉受体细胞的功能和形态再生研究，以及免疫系统在这些感觉受体再生中的作用。虽然共享相同感觉系统的项目之间存在明显的共性（例如， 听觉系统）和相同的实验焦点（例如，开发或再生），所有项目之间存在着重大的科学和技术重叠。 因此，本提案中详细介绍的实验共同形成了一个多学科性质的研究计划，非常适合研究外周感觉系统发育和再生的基本和及时问题。

The development and regeneration of peripheral sensory receptors involve dynamic biological processes in which progenitor cells ultimately form mature, functional receptors capable of transducing environmental stimuli. Such processes include induction7 proliferation and differentiation, migration to the proper destinations, structural and functional maturation, maintenance of the cell cycle, and connections with the proper neural units. While these processes-are shared among sensory systems, important characteristics are unique to each Through a coordinated study of the commonalities and differences among the developing and regenerating systems, it will be possible to provide organizing principles that allow an understanding of peripheral sensory cell development and of sensory cell regeneration in response to injury. Thus, the long term goal of this Program Project Grant (PPG) is to examine common and unique processes during development and regeneration o sensory receptor cells in related sensory systems. Specifically, we will study olfactory, auditory, and gustatory receptor cell development and regeneration. The PPG is divided into three main, integrated projects that exploit the expertise and collaborative efforts of the investigators affiliated with the Program. In Project 1 the early embryonic induction of olfactory- and auditory-related structures will be studied. Projects 2 and 3 involve studies of the functional and morphological regeneration of mammalian auditory hair cells and gustatory receptor cells, respectively, and the role of the immune system in the regeneration of these sensory receptors. While clear commonalities exist among projects that share the same sensory system (e.g., auditory system) and the same experimental focus (e.g., development or regeneration), significant scientific and technical overlap is present among all projects. Therefore, experiments detailed in this proposal collectively form a program of study that is multidisciplinary in nature and ideally suited to investigate fundamental and timely issues common to peripheral sensory system development and regeneration.