PERIPHERAL SENSORY SYSTEM DEVELOPMENT & REGENERATION

外周感觉受体的发育和再生涉及动态的生物学过程，在这个过程中，祖细胞最终形成能够传递环境刺激的成熟的、有功能的受体。这些过程包括诱导增殖和分化，迁移到适当的目的地，结构和功能成熟，维持细胞周期，以及与适当的神经单位连接。虽然这些过程在感觉系统之间是共享的，但通过对发育和再生系统之间的共性和差异进行协调研究，每个系统的重要特征都是独特的，因此有可能提供组织原则，使人们能够理解周围感觉细胞的发育和对损伤的感觉细胞再生。因此，该计划项目赠款(PPG)的长期目标是研究相关感觉系统中感觉感受器细胞在发育和再生过程中的共同和独特的过程。具体地说，我们将研究嗅觉、听觉和味觉感受器细胞的发育和再生。PPG分为三个主要的综合项目，利用与该计划有关的调查人员的专业知识和合作努力。在项目1中，将研究嗅觉和听觉相关结构的早期胚胎诱导。项目2和3分别涉及哺乳动物听觉毛细胞和味觉受体细胞的功能和形态再生的研究，以及免疫系统在这些感觉受体再生中的作用。尽管共享相同感官系统(例如，听觉系统)和相同实验重点(例如，发育或再生)的项目之间存在明显的共性，但所有项目之间存在重大的科学和技术重叠。因此，本建议中详述的实验共同形成了一个多学科性质的研究计划，非常适合研究外周感觉系统发展和再生共同的基本和及时的问题。

The development and regeneration of peripheral sensory receptors involve dynamic biological processes in which progenitor cells ultimately form mature, functional receptors capable of transducing environmental stimuli. Such processes include induction7 proliferation and differentiation, migration to the proper destinations, structural and functional maturation, maintenance of the cell cycle, and connections with the proper neural units. While these processes-are shared among sensory systems, important characteristics are unique to each Through a coordinated study of the commonalities and differences among the developing and regenerating systems, it will be possible to provide organizing principles that allow an understanding of peripheral sensory cell development and of sensory cell regeneration in response to injury. Thus, the long term goal of this Program Project Grant (PPG) is to examine common and unique processes during development and regeneration o sensory receptor cells in related sensory systems. Specifically, we will study olfactory, auditory, and gustatory receptor cell development and regeneration. The PPG is divided into three main, integrated projects that exploit the expertise and collaborative efforts of the investigators affiliated with the Program. In Project 1 the early embryonic induction of olfactory- and auditory-related structures will be studied. Projects 2 and 3 involve studies of the functional and morphological regeneration of mammalian auditory hair cells and gustatory receptor cells, respectively, and the role of the immune system in the regeneration of these sensory receptors. While clear commonalities exist among projects that share the same sensory system (e.g., auditory system) and the same experimental focus (e.g., development or regeneration), significant scientific and technical overlap is present among all projects. Therefore, experiments detailed in this proposal collectively form a program of study that is multidisciplinary in nature and ideally suited to investigate fundamental and timely issues common to peripheral sensory system development and regeneration.