FLUORESCENCE EEM SPECTROSCOPY TO DETECT DYSPLASIA IN EPITHELIAL TISSUES: CANCER

荧光 EEM 光谱检测上皮组织发育不良：癌症

• 批准号: 6121221
• 负责人: QINGGUO ZHANG
• 金额: $ 2.86万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121221
• 关键词: biomedical equipment development; biomedical resource; human tissue; oral pharyngeal; technology /technique; urinary tract

We have developed in vivo EEM system which can collect 10 fluorescence spectra excited with 10 different light sources and diffuse reflectance spectra from the same tissue in less than a second. This system is currently being used to study precancerous changes in Barrett's esophagus and colon. So far we have examined nearly 55 patients undergoing surveillance for dysplasia in Barrett's esophagus. The system is also being used at the Brigham and Women's Hospital for studying adenomatous polyps and dysplasia in colon. The wealth of fluorescence information provided by rapid EEM system is being analyzed using model based approach and principal component analysis approach.

我们开发了活体EEM系统，可以收集10个 用10种不同光源激发的荧光光谱和 同一组织的漫反射光谱在不到一 第二。这一系统目前正被用于研究癌前病变 巴雷特的食道和结肠的变化。到目前为止，我们已经检查了 近55名患者接受Barrett‘s异型增生监测 食管。该系统也在布里格姆和女子酒吧使用 结肠腺瘤性息肉和异型增生研究医院。这个 快速EEM系统提供的丰富荧光信息是 使用基于模型的方法和主成分进行分析 分析方法。