PCBS AND WELL BEING OF MOHAWK CHILDREN AND YOUTH--GROWTH, DEVELOPMENT, COGNITION

PCBS 与莫霍克儿童和青少年的福祉——成长、发展、认知

• 批准号: 6217632
• 负责人: LAWRENCE M SCHELL
• 金额: $ 23.08万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6217632
• 关键词: Native Americans; adipose tissue; adolescence (12-20); behavioral /social science research tag; body composition; child physical development; child psychology; dietary iron; environmental toxicology; halobiphenyl /halotriphenyl compound; hormone regulation /control mechanism; human puberty; human subject; lead; mercury; middle childhood (6-11); nutrition related tag; sex hormones; thyroid hormones; thyrotropin

This research seeks to identify the consequences of exposure to PCBs and other toxins in the environment on the health of children and youth as measured by their physical growth and maturation and by their cognitive/behavioral development. There are two general objectives of this research, 1) to identify the effects of PCB body burden on endocrines that reflect thyroid function and sexual maturation, and on the physical growth, maturation and cognitive development of children and youth and, 2) to identify the role of body composition, specifically fat stores, in determining the level of PCBs in circulation and as a modifier of their effects. A cross-sectional study of mohawk children and youth 10-16 years of age (anticipated n=400) will permit determination of the relationships of PCB level to endocrines (thyroxine, triiodothyroine, thyrotropin, and beta-estradiol / testosterone), physical growth, maturation and cognitive- behavioral functioning as well as the influence of fat mass or percent fat on PCB levels and PCB effects. Exposure to PCBs is determined by serum assay, and the primary outcomes are assessed by direct examination (anthropometry and several measures of cognitive and behavioral functioning), or in the case of endocrines, by blood analysis. Body composition (fat mass, percent fat) is determined using multiple anthropometric measures (primarily skinfolds, circumferences and bony breadths). The study will also collect information on other factors that affect the outcomes of interest and, when necessary, control them through statistical methods. The study will determine levels of blood mercury (organic and inorganic), lead, and the level of fluoride in urine because the population at Akwesasne are exposed to these toxins that may affect growth and development. Other influences (for example, diet, socio- economic status, birth order, and others) are assessed through questionnaire. Iron status is assessed through blood assay. Multiple regression techniques, particularly structural equation analysis, of these data will permit control of the known influences on the outcomes of interest and the estimation of direct and indirect effects of PCBs on the intermediate and final outcomes of interest.

这项研究旨在确定暴露于PCB和PCB的后果 环境中其他关于儿童和青少年健康的毒素 通过其身体成长和成熟以及他们的 认知/行为发展。 有两个一般目标的 这项研究，1）确定PCB身体负担对内分泌的影响 这反映了甲状腺功能和性成熟，以及物理 儿童和青少年的成长，成熟和认知发展，2） 确定身体成分，特别是脂肪存储的作用， 确定流通中的PCB水平，并作为其修饰符 效果。 对莫霍克族儿童和青少年10-16岁的横断面研究 年龄（预期n = 400）将允许确定关系 内分泌的PCB水平（甲状腺素，三碘甲状腺素，甲状腺蛋白和 β-雌二醇 /睾丸激素），身体生长，成熟和认知 - 行为功能以及脂肪质量或脂肪百分比的影响 在PCB水平和PCB效应上。 暴露于PCBS由血清确定 测定和主要结果通过直接检查评估 （人体测定法以及认知和行为的几种措施 功能），或通过血液分析的情况。 身体 组成（脂肪质量，脂肪百分比）使用多个 人体测量指标（主要是皮肤折，圆周和骨 广度）。 该研究还将收集有关其他因素的信息 影响感兴趣的结果，并在必要时通过 统计方法。 该研究将确定血液汞的水平 （有机和无机），铅和尿液中的氟化物水平，因为 Akwesasne的人口暴露于这些可能影响的毒素 增长与发展。 其他影响（例如，饮食，社会 - 经济状况，出生顺序和其他人）通过 问卷。 铁状态是通过血液测定评估的。 多种的 回归技术，尤其是结构方程分析， 数据将允许控制已知影响的影响 PCB对PCB的直接和间接影响的兴趣和估计 感兴趣的中级和最终结果。