ROLE OF THE ACCESSORY OPTIC SYSTEM IN THE VERTICAL VOR

附件光学系统在垂直 VOR 中的作用

• 批准号: 6135874
• 负责人: JON M LOCKARD
• 金额: $ 2.03万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6135874
• 关键词: Saimiri; brain electrical activity; eye movements; vestibuloocular reflex; visual pathways

The long-range goal of the proposed project is to explore the responses of the lateral terminal nucleus of the accessory optic system (LTN) and the dorsolateral pontine nucleus (DLPN) in the squirrel monkey in relation to vertical eye movements and eventually to motor learning of the vertical vestibulo ocular reflex (VVOR). To accomplish this goal, three experiments are proposed: (1) The nature of visual information and its flow will be monitored in the LTN and DLPN by extracellular single unit recording to characterize their activity during VVOR and vertical optokinetic nystagmus (VOKN). (2) Once the LTN and DLPN have been characterized we will temporarily inactivate them with muscimol or lidocaine to assess the effects of their inactivation on the normal VVOR and VOKN. (3) The neural pathways conveying visual information to the vertical VOR and vertical OKN cerebellar and brainstem pathways, the LTN and the DLPN, will be anatomically defined in the squirrel monkey. The simplicity of the oculomotor system makes it compelling for study when compared to the complexity of the skeletal motor system. Yet the results of eye movement studies have had a profound impact on understanding the function of motor, sensory, and cognitive systems of vertebrate and human behavior.

该项目的长期目标是探索松鼠猴的副视系统（LTN）和背外侧脑桥核（DLPN）的外侧终核与垂直眼球运动的反应，并最终与垂直前庭眼反射（VVOR）的运动学习有关。为了实现这一目标，我们提出了三个实验：（1）在VVOR和垂直视动性眼球震颤（VOKN）过程中，通过细胞外单单位记录来监测LTN和DLPN中视觉信息的性质及其流动，以表征它们的活动。(2)一旦LTN和DLPN被表征，我们将暂时用蝇蕈醇或利多卡因将其灭活，以评估其对正常VVOR和VOKN的影响。(3)将视觉信息传递到垂直VOR和垂直OKN小脑和脑干通路（LTN和DLPN）的神经通路将在松鼠猴中进行解剖学定义。与骨骼运动系统的复杂性相比，眼球运动系统的简单性使其更值得研究。然而，眼动研究的结果对理解脊椎动物和人类行为的运动、感觉和认知系统的功能产生了深远的影响。