PLACENTA CHANGE ASSOC W/ FETAL OUTCOME: PLASMODIUM COATNEYI/RHESUS MALARIA MODEL

猴子1次流产和7次足月妊娠的胎盘 在妊娠前三个月(T-1)接种Coatneyi 已评估。结果与总寄生虫载量相关。 (TPL)、发病率和胎儿/婴儿结局。TPL被定义为总和 每三个月的每周寄生虫计数。协会是 经Spearman等级相关分析。由以下内容组成的控制 5个胎盘取自无疟原虫暴露史的猴子。这个 7个来自感染疟原虫的母体的胎盘 病理改变明显高于对照组(P&lt；0.05)。三只猴子吃得高 T-1 TPL中止。妊娠早期高TPL与 流产(p=0.0476)或胎盘损伤增加(p&lt；0.05)。低出生 体重(LBW)和胎儿宫内发育迟缓(IUGR) 与高疟疾色素评分和大量 巨噬细胞。随着妊娠晚期TPL的增加， 母血巨噬细胞(p&lt；0.05)和色素评分(p&lt；0.05) 增加了。随着色素的增加，婴儿体重下降(p&lt；0.05)。AS 巨噬细胞增多，婴儿体重减少(p&lt；0.05)。高胎盘 损伤评分与IUGR、LBW或早产儿无关 死亡率。Funding Base Grant出版物Davison BB，Cogswell FB， 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细内容胎盘改变 柯特伊疟原虫/恒河猴与胎儿结局的关系 孕期疟疾模型的建立。提交的《热带医学杂志》 和《卫生》，1999年。

Placentas from one abortion and 7 term pregnancies from monkeys inoculated with P. coatneyi during the first trimester (T-1) were evaluated. The results were correlated with total parasite load (TPL), morbidity and fetal/infant outcome. TPL was defined as the sum of all weekly parasite counts for each trimester. Associations were compared by Spearman Rank correlates analysis. Controls consisted of 5 placentas from monkeys with no history of Plasmodium exposure. The 7 placentas from Plasmodium-infected dams had more significant pathologic changes than controls (p< 0.05). Three monkeys with high T-1 TPL aborted. High TPL during early gestation was associated with abortion(p=0.0476) or increased placental damage (p<0.05). Low birth weight (LBW) and intrauterine growth retardation (IUGR) were associated with high malaria pigment scores and high numbers of macrophages. As TPL during late gestation increased, the number of maternal macrophages (p<0.05) and the pigment scores (p<0.05) increased. As pigment increased, infant wt. decreased (p<0.05). As macrophages increased, infant wt. decreased (p<0.05). High placental damage scores were not associated with IUGR, LBW, or early infant mortality. FUNDING Base Grant PUBLICATIONS Davison BB, Cogswell FB, Baskin GB, Falkenstein KP, Henson EW, Krogstad, DJ. Placental Changes Associated With Fetal Outcome In The Plasmodium Coateyi/Rhesus Monkey Model Of Malaria In Pregnancy. Submitted Journal of Tropical Medicine and Hygiene, 1999.