A RHESUS MONKEY MODEL OF MALARIA DURING PREGNANCY

怀孕期间疟疾的恒河猴模型

基本信息

  • 批准号:
    7562248
  • 负责人:
  • 金额:
    $ 3.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-05-01 至 2008-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We developed a rhesus monkey model to examine the effects of malaria (Plasmodium coatneyi) during pregnancy. This project, supported by an NIH R01, explores maternal immunologic responses, In a prospective study of rhesus monkeys inoculated with Plasmodium coatneyi or saline on an infection/gestational timeline, we determined the serum levels of tumor necrosis factor-alpha (TNF-alpha), soluble tumor necrosis factor receptor type I (sTNFR-I), and soluble tumor necrosis factor receptor type II (sTNFR-II) in peripheral blood throughout primigravid pregnancy, malaria infection, and a combination of the two. Our goal was to determine the association between levels of TNF-alpha and of its 2 soluble receptors and the course of pregnancy and/or malaria and infant outcome. We found that any detectable level of TNF-alpha was always associated with fetal death and that the sTNFRs may be important for fetal protection, possibly through neutralizing the toxic effects of TNF-alpha. Our findings also showed that increased levels of sTNFR-II were associated specifically with malaria and not with normal pregnancy or even pregnancy with low birth weight due to other causes. In contrast, increases in sTNFR-I levels during the later half of normal pregnancies indicate that sTNFR-I may be important in regulating TNF-alpha levels in preparation for normal labor and delivery.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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BILLIE B DAVISON其他文献

BILLIE B DAVISON的其他文献

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{{ truncateString('BILLIE B DAVISON', 18)}}的其他基金

CONSORTIUM FOR ANTIMALARIAL DEVELOPMENT
抗疟开发联盟
  • 批准号:
    7348998
  • 财政年份:
    2006
  • 资助金额:
    $ 3.04万
  • 项目类别:
MALARIA IMMUNOLOGY AND GENETICS IN THE AMAZON (MIGIA) PROJECT
亚马逊 (MIGIA) 项目中的疟疾免疫学和遗传学
  • 批准号:
    7349085
  • 财政年份:
    2006
  • 资助金额:
    $ 3.04万
  • 项目类别:
A RHESUS MONKEY MODEL OF MALARIA DURING PREGNANCY
怀孕期间疟疾的恒河猴模型
  • 批准号:
    7348973
  • 财政年份:
    2006
  • 资助金额:
    $ 3.04万
  • 项目类别:
A RHESUS MONKEY MODEL OF MALARIA DURING PREGNANCY
怀孕期间疟疾的恒河猴模型
  • 批准号:
    7165018
  • 财政年份:
    2005
  • 资助金额:
    $ 3.04万
  • 项目类别:
PROMPT TREATMENT OF PARASITEMIA DURING PREGNANCY LIMITS PLACENTAL PATHOLOGY
妊娠期间及时治疗寄生虫血症可限制胎盘病理学
  • 批准号:
    7165091
  • 财政年份:
    2005
  • 资助金额:
    $ 3.04万
  • 项目类别:
CONSORTIUM FOR ANTIMALARIAL DEVELOPMENT
抗疟开发联盟
  • 批准号:
    7165053
  • 财政年份:
    2005
  • 资助金额:
    $ 3.04万
  • 项目类别:
CELLULAR RESPONSES ASSOCIATED WITH MALARIA IN PREGNANCY
与妊娠期疟疾相关的细胞反应
  • 批准号:
    6970762
  • 财政年份:
    2004
  • 资助金额:
    $ 3.04万
  • 项目类别:
PROMPT TREATMENT OF PARASITEMIA DURING PREGNANCY
怀孕期间及时治疗寄生虫血症
  • 批准号:
    6970812
  • 财政年份:
    2004
  • 资助金额:
    $ 3.04万
  • 项目类别:
A RHESUS MONKEY MODEL OF MALARIA DURING PREGNANCY
怀孕期间疟疾的恒河猴模型
  • 批准号:
    6970716
  • 财政年份:
    2004
  • 资助金额:
    $ 3.04万
  • 项目类别:
A RHESUS MONKEY MODEL OF MALARIA DURING PREGNANCY
怀孕期间疟疾的恒河猴模型
  • 批准号:
    6939739
  • 财政年份:
    2003
  • 资助金额:
    $ 3.04万
  • 项目类别:

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  • 财政年份:
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