NEONATAL TESTOSTERONE & PRIMATE SEXUAL & IMMUNE DEVELOPMENT

新生儿睾酮

• 批准号: 6116267
• 负责人: DAVID R MANN
• 金额: $ 7.88万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116267
• 关键词: Mammalia; communicable diseases; endocrine gland /system; growth /development; lymphatic system; male; mother /infant health care; reproductive system

The effect of neonatal treatment with a gonadotropin releasing hormone (GnRH) antagonist on sexual and immune system development and function is being assessed in male monkeys maintained in a social group under natural lighting conditions. The disruption of neonatal activity of the hypothalamic-pituitary-testicular axis retarded sexual development, but did permanently block the achievement of reproductive competence. Social rank was a major factor in determining the tempo of sexual maturation, and the influence of this regulatory factor could not be overriden by neonatal treatment with testosterone. Treated animals showed abnormal developmental patterns of lymphocyte subsets, and as adults were immunosuppressed. Cell- and humoral-mediated immunity of treated animals were subnormal, but social rank did not impact on immune function. Immune function varied with season in all animals, but this seasonality was especially pronounced in control monkeys. The results s upport th e contention that the neonatal period is a critical interval in development, and that endocrine perturbations during this period alters sexual maturation and the ability of the animal to respond to antigenic challenge. It also appears that immune function in the rhesus monkey varies with seasons, an effect that may be mediated by circannual fluctuations in immunoactive hormones. FUNDING NIH / HD2643 $113,627 4/01/95 - 3/31/99 PUBLICATIONS *Gould, K.G., Akinbami, M.A. and Mann, D.R. Effect of neonatal treatment with a gonadotropin releasing hormone antagonist on developmental changes in circulating lymphocyte subsets A longitudinal study in male rhesus monkeys. Developmental and Comparative Immunology 22:457-467, 1998. Mann, D.R., Howie, S., Paulsen, D.R., Akinbami, M.A., Lunn, S.F. and Fraser, H.M. Changes in lymphoid tissue after treatment with a gonadotropin releasing hormone antagonist in the neonatal marmoset (Callithrix jacchus). Amer. J. Reprod. Immunol. 39:256-265, 1998. *Mann, D.R., Akinbami, M.A., Gould, K.G., Paul, K. and Wallen, K. Sexual maturation in male rhesus monkeys Importance of neonatal testosterone exposure and social rank. J. Endocrinology, 156:493-501, 1998.

促性腺激素释放的新生儿治疗的作用 关于性和免疫系统发展的激素（GNRH）拮抗剂 在社会中维持的雄性猴子中正在评估功能 在自然照明条件下组。 新生儿的破坏 下丘脑 - 垂体 - 固有轴的活性 开发，但确实永久阻止了生殖的成就 权限。 社会等级是确定节奏的主要因素 性成熟和该法规因素的影响 用睾丸激素治疗新生儿治疗不能过度。 治疗的动物显示出异常的淋巴细胞发育模式 子集，成年人被免疫抑制。 细胞和 治疗动物的体液介导的免疫力是亚正常，但 社会等级对免疫功能没有影响。 免疫功能变化 在所有动物中都有季节，但尤其是这种季节性 在控制猴子中发音。 结果提出了争论 新生儿时期是发展的关键间隔， 在此期间，内分泌的扰动改变了性 成熟和动物对抗原反应的能力 挑战。 看来恒河猴中的免疫功能 随季节而异，这可能是由Circanual介导的 免疫活性激素的波动。 资金NIH / HD2643 $ 113,627 4/01/95-3/31/99出版物 *Gould，K.G。，Akinbami，M.A。和Mann， D.R.促性腺激素释放的新生儿治疗的影响 激素拮抗剂在循环淋巴细胞的发育变化上 子集在雄性恒河猴中进行纵向研究。 发展 和比较免疫学22：457-467，1998。Mann，D.R。，Howie，S.， Paulsen，D.R.，Akinbami，M.A.，Lunn，S.F。和弗雷泽（H.M.）变更 用促性腺激素释放激素治疗后淋巴组织 新生儿果泥（Callithrix jacchus）中的对手。 阿米尔。 J. 复制。 免疫。 39：256-265，1998。 *Mann，D.R。，Akinbami，M.A。， 古尔德（K.G.），保罗（K. 猴子的新生儿睾丸激素暴露和社会等级的重要性。 J.内分泌学，156：493-501，1998。