Development and Differentiation in Reproductive Axis

生殖轴的发育和分化

• 批准号: 6920146
• 负责人: DAVID R MANN
• 金额: $ 20.95万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-26 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6920146
• 关键词: cell differentiation; cooperative study; growth /development; hormone regulation /control mechanism; reproductive system

DESCRIPTION (provided by applicant): The mission of the proposed Cooperative Reproductive Science Research Center (CRSRC) at Morehouse School of Medicine (MSM) is to develop a rich intellectual environment that will promote and strengthen the research capabilities of the MSM investigators in the reproductive sciences. The applicant's ultimate goal is to become a research and training Center of excellence for minority investigators. To achieve this goal, the applicant proposes to develop a partnership between the CRSRC at the MSM and the Specialized Cooperative Center Program of Reproduction Research (SCCPRR) at the University of Pittsburgh. The CRSRC at the MSM will be composed of four Research Projects and an Administrative Core. The central theme of the proposal focuses on Development and Differentiation within the Reproductive Axis with emphasis on non-human primate paradigms. The proposed studies will integrate molecular, cellular and organismic approaches for elucidating physiological mechanisms that govern sexual development, follicular maturation, luteolysis and spermatogenesis. Each Research Project is led by a MSM Principal Investigator who works closely with at least one SCCPRR investigator at Pittsburgh. The experience and expertise of the SCCPRR Director and his colleagues will be employed to assure the successful operation of the CRSRC. The CRSRC will utilize extensively the research resources made available via the partnership. Three Research Projects (I, II, and III) will be subserved by both the Primate and Assay Cores of the Pittsburgh SCCPRR, and three (II, III, and IV) will use the Cell-Imaging Core. The Pittsburgh SCCPRR will benefit from the scientific interaction with individuals at the MSM with similar interests, and from the association with a minority institution that will serve as a conduit for the recruitment of minority students, fellows and residents to Pittsburgh training programs. The partnership will also substantially increase use of the Core facilities at Pittsburgh by projects relevant to the mission of the Reproductive Sciences Branch, NICHD. The proposed research will lead to a better understanding of the causes of disorders of human reproduction and may ultimately result in improved therapeutic approaches to infertility and to development of novel strategies for contraception.

描述（由申请人提供）：拟议合作社的任务 莫尔豪斯医学院的生殖科学研究中心（CRSRC） （MSM）是建立一个丰富的智力环境，以促进和 增强MSM调查人员的研究能力 生殖科学。申请人的最终目标是成为一项研究 和少数派研究人员卓越培训中心。实现这一目标 目标，申请人建议在CRSRC之间建立合作伙伴关系 MSM和专业合作中心繁殖研究计划 （SCCPRR）在匹兹堡大学。 MSM的CRSRC将是 由四个研究项目和一个行政核心组成。中央 该提案的主题着重于在 生殖轴，重点是非人类灵长类动物范式。提议 研究将整合分子，细胞和生物学方法 阐明控制性发展的生理机制， 卵泡成熟，黄体溶解和精子发生。每个研究项目 由MSM首席调查员领导，他与至少一个密切合作 匹兹堡的SCCPRR调查员。 SCCPRR的经验和专业知识 董事及其同事将被聘请确保成功 CRSRC的操作。 CRSRC将广泛利用研究 通过合作伙伴关系提供的资源。三个研究项目（i，ii， 和iii）将由灵长类动物和测定核心所需的 匹兹堡SCCPRR和三个（II，III和IV）将使用细胞成像核心。 匹兹堡SCCPRR将受益于与 MSM的个人具有相似的兴趣，以及与 将作为招募的渠道的少数族裔机构 少数民族学生，研究员和居民参加匹兹堡培训计划。这 合作伙伴关系还将大大增加对核心设施的使用 匹兹堡通过与生殖科学任务有关的项目 分支机构，Nichd。拟议的研究将使人们更好地理解 人类繁殖障碍的原因，最终可能导致 改善了不孕症的治疗方法和新颖的发展 避孕策略。