EXAMINATION OF DIFFERENTIAL SENSITIVITY TO STRESS DURING PUBERTAL PERIOD

青春期压力敏感性差异的检查

• 批准号: 6592321
• 负责人: JUDY L CAMERON
• 金额: $ 11.11万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6592321
• 关键词: Mammalia; behavioral /social science research tag; carbohydrates; cardiovascular system; clinical research; communicable diseases; diabetes mellitus; endocrine gland /system; growth /development; immunology; inflammation; nervous system; pancreas; physical fitness; psychology; reproductive system; skeletal system; women's health

The overall goal of this grant is to experimentally test the hypothesis that the pubertal period represents a Awindow of heightened sensitivity@ to external perturbations that may have long-term health consequences. Specifically, this project is determining whether monkeys going through the pubertal transition are more sensitive to the various health consequences of social stress and moderately vigorous exercise training than monkeys in the early post-pubertal period. The health consequences that are being monitored are (1) reproductive function, including menstrual cyclicity and reproductive hormone secretion, (2) bone structure and growth, (3) body fat distribution, (4) serum lipid content, (5) glucose tolerance, (6) immune function, (7) susceptibility to viral infection, and (8) cardiovascular function, including resting heart rate, heart rate response to stress, and echocardiographic measurements. These parameters are being studied because they are known to be i nfluenced by social stress and exercise and they are all thought to be affected by reproductive steroid hormone levels. Thus, they are likely to be affected by the pubertal transition as well as by the external perturbations that are being studied. FUNDING The John D. and Catherine T. MacArthur Foundation PUBLICATIONS Rogers CJ, Brissette-Storkus CS, Hayes LA, Cameron JL, Chambers WH. Selective reduction in CD2 expression on CD2bright/CD8+ lymphocytes from cynomolgus monkeys (Macaca fascicularis) in response to acute stress. J Neuroimmunol 86:61-72, 1998. Rogers CJ., Brissette-Storkus CS, Chambers WH, Cameron JL. Acute stress-induced increase in NK cell granule content in monkeys. Soc Neurosci Abstr 24:1862,1998 (abstract 739.2). Rogers CJ, Brissette-Storkus CS, Cameron JL, Chambers WH. Acute stress alters both NK cell conjugation and lytic granule content in monkeys. Society for Natural Immunity Abstract, 1998.

这笔赠款的总体目标是实验测试 假设青春期代表了增强 敏感性@对可能具有长期健康的外部扰动 结果。 具体而言，该项目正在确定是否 经过青春期过渡的猴子对 社会压力的各种健康后果和适度 剧烈的锻炼训练比猴子早期的猴子 时期。 正在监测的健康后果是（1） 生殖功能，包括月经和生殖 激素分泌，（2）骨结构和生长，（3）体内脂肪 分布，（4）血清脂质含量，（5）葡萄糖耐受性，（6） 免疫功能，（7）对病毒感染的敏感性，（8） 心血管功能，包括静息心率，心率 对压力和超声心动图测量的响应。 这些 正在研究参数，因为众所周知 通过社会压力和运动，他们都被认为受到影响 通过生殖类固醇激素水平。 因此，他们可能是 受青春期过渡以及外部的影响 正在研究的扰动。 资助John D.和 凯瑟琳·T·麦克阿瑟基金会出版物罗杰斯CJ， Brissette-Storkus CS，Hayes LA，Cameron JL，Chambers WH。 选择性 从CD2Bright/CD8+淋巴细胞上的CD2表达降低 cynomolgus猴子（Macaca fascicularis）响应急性应激。 J Neuroimmunol 86：61-72，1998。Rogers CJ。，Brissette-Storkus CS， 钱伯斯WH，卡梅隆JL。 急性应力诱导的NK细胞增加 猴子中的颗粒含量。 Soc Neurosci Abstr 24：1862，1998（摘要 739.2）。 Rogers CJ，Brissette-Storkus CS，Cameron JL，Chambers WH。 急性应力改变NK细胞结合和裂解颗粒含量 在猴子。 自然免疫学会摘要，1998年。