CHOLERA TOXIN

霍乱毒素

• 批准号: 6116350
• 负责人: MARNIX L BOSCH
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116350
• 关键词: Primates; infection; intestines; lymphatic system; vaccines

To determine whether cholera toxin can induce mucosal immunity in macaques, we inoculated two pigtailed macaques intrarectally. When we tested various bodily fluids for antibodies to cholera toxin following inoculation, we found high titers in blood and lower titers in rectal and vaginal washes. The response was stronger in one monkey than in the other. We believe that improved sampling techniques will provide a better picture of the induced immune response.

为了确定霍乱毒素是否能诱导猕猴粘膜免疫，我们对两只尾尾猕猴进行了直肠内接种。当我们在接种后测试各种体液中的霍乱毒素抗体时，我们发现血液中的抗体滴度高，而直肠和阴道洗液中的抗体滴度较低。其中一只猴子的反应比另一只更强烈。我们相信，改进的采样技术将提供一个更好的图片诱导免疫反应。