TRANSMISSION OF KAPOSIS SARCOMA & RETROPERITONEAL FIBROMATOSIS IN MACAQUES: AIDS

卡波济斯肉瘤的传播

• 批准号: 6116321
• 负责人: MARNIX L BOSCH
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116321
• 关键词: AIDS; Mammalia; Primates; gene therapy; immunology; infection; inflammation; lymphatic system; model design /development; neoplasm /cancer; virus

Kaposi's sarcoma is a neoplastic disease associated with AIDS, and retroperitoneal fibromatosis is a disease of macaques that is related to Kaposi's sarcoma. In this project we investigated infections of rhesus and cynomolgus macaques with retroperitoneal fibromatosis-associated herpesvirus (RFHV). Animals infected with RFHV showed signs of lymphoproliferative disease and developed an unusual proliferative arteriopathy. Transfer of RFHV into cynomolgus macaques resulted in a rapidly fatal myeloproliferative disorder characterized by circulating multinucleated giant cells. We also attempted to infect pigtailed macaques with Kaposi's sarcoma-associated herpesvirus, but were unable to demonstrate productive infection in these animals.

卡波西肉瘤是一种与艾滋病相关的肿瘤性疾病，腹膜后纤维瘤病是一种与卡波西肉瘤相关的猕猴疾病。 在这个项目中，我们调查了恒河猴和食蟹猴感染腹膜后纤维瘤病相关疱疹病毒（RFHV）。 感染RFHV的动物表现出淋巴组织增生性疾病的体征，并出现了不寻常的增生性动脉病。 将RFHV转移到食蟹猴中导致以循环多核巨细胞为特征的快速致死性骨髓增生性疾病。 我们还尝试用卡波西肉瘤相关疱疹病毒感染猪尾猕猴，但无法证明在这些动物中的生产性感染。