INFECTION OF MACAQUE NEONATES W/ HIV 1 BY ORAL ADMINISTRATION

口服 HIV 1 型猕猴新生儿感染

• 批准号: 6116322
• 负责人: MARNIX L BOSCH
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116322
• 关键词: AIDS; Mammalia; Primates; immunology; infection; inflammation; lymphatic system; model design /development; virus

Receptive anal intercourse, but not orogenital sex, has been identified as a major risk factor for transmission of human immunodeficiency virus type I (HIV-1). In this study we inoculated newborn pigtailed macaques with HIV-1 via various mucosal routes. None of the animals inoculated orally became infected, whereas four of the five animals inoculated rectally did become infected. From this we conclude that oral inoculation is not as efficient as rectal inoculation in the transmission of HIV-1. On the other hand, the orally inoculated animals failed to thrive, indicating that perhaps HIV-1 did affect these animals in the absence of overt systemic infection.

接受性肛交，而不是口生殖器性交，已被确定为人类免疫缺陷病毒I型（HIV-1）传播的主要危险因素。在这项研究中，我们通过不同的粘膜途径给新生的尾猴接种了HIV-1。经口腔接种的动物无一感染，而经直肠接种的5只动物中有4只感染。由此我们得出结论，在HIV-1的传播中，口服接种不如直肠接种有效。另一方面，口服接种的动物没有茁壮成长，这表明也许HIV-1在没有明显的全身感染的情况下确实影响了这些动物。