LEAD MOBILIZATION DURING PREGNANCY AND LACTATION IN URBAN WOMEN
城市女性孕期和哺乳期的铅动员
基本信息
- 批准号:6217756
- 负责人:
- 金额:$ 8.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-04-01 至 2001-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Case reports suggest that lead stored in the skeleton is mobilized during
pregnancy and lactation, placing the mother and, in particular, the
developing fetus at risk of lead poisoning. The placenta is fully
permeable to lead. To investigate the hypothesis that skeletal lead is
mobilized during pregnancy and lactation, we propose a prospective cohort
study with repeated measures of blood, plasma and bone lead in an
ethnically diverse population of young, inner city women. We hypothesize
that as lead is mobilized during pregnancy and lactation, maternal and
fetal blood lead levels will increase and maternal bone lead levels will
decrease.
We will compare bone, plasma and whole blood lead levels prior to
pregnancy with measurements obtained from the same women in the immediate
postpartum period and six months after delivery. We hypothesize that
bone lead levels will decrease and blood lead levels will increase as a
result of lead mobilization during pregnancy. Among women who breast
feed, the six month postpartum measurements will assess any additional
effect of lactation on lead mobilization. Similar comparisons will also
be made in a control group of non-pregnant women. The control group will
allow us to compare the natural history of bone lead changes in the
absence of pregnancy and lactation. Umbilical cord blood lead levels
will be determined to assess maternal transfer of circulating lead to the
neonate.
This study population is expected to have a high body lead burden as a
result of environmental lead exposure. The ethnic diversity of this
population will enable us to determine whether body lead burdens are
higher in African-American and Hispanic women than in Caucasian women.
We will also assess whether women with higher body lead burden at
baseline mobilize more lead than women with lower baseline body lead
burden.
Adequate iron stores have been shown to protect against lead absorption
and therefore, possibly protect against lead mobilization during
pregnancy. This study will investigate the effect of iron stores on body
burden of lead in two ways. First, we will determine whether higher iron
stores, assessed by serum ferritin levels, predict a lower body burden
of lead. Secondly, we will determine whether the level of iron stores
affects lead mobilization during pregnancy by comparing serum ferritin
levels with bone, blood and plasma lead measurements before and after
pregnancy.
This study will provide the first quantitative examination of the
hypothesis that skeletal lead mobilization occurs during pregnancy and
lactation. The investigation should provide important insights into the
potential health effects of chronic environmental lead exposure to
pregnant women, developing fetuses and infants through breast feeding.
病例报告表明,储存在骨骼中的铅在
怀孕和哺乳期,将母亲,特别是
发育中的胎儿有铅中毒的风险。 胎盘已完全
可渗透铅。 研究骨骼铅的假设
在怀孕和哺乳期间动员起来,我们提出了一个前瞻性队列
重复测量血液、血浆和骨铅的研究
内城年轻女性的种族多元化。 我们假设
由于铅在怀孕和哺乳期间被动员,母亲和
胎儿血铅水平会升高,母体骨铅水平也会升高
减少。
我们将在治疗前比较骨、血浆和全血铅水平
怀孕后立即从同一女性获得测量结果
产后期和产后六个月。 我们假设
骨铅水平将降低,血铅水平将升高
怀孕期间铅动员的结果。 在乳房的女性中
喂养,产后六个月的测量将评估任何额外的
哺乳对铅动员的影响。 类似的比较也会
在非怀孕妇女的对照组中进行。 对照组将
让我们能够比较骨铅变化的自然历史
没有怀孕和哺乳。 脐带血铅水平
将确定评估母体循环铅转移到
新生儿。
该研究人群预计具有较高的身体铅负担
环境铅暴露的结果。 这个种族的多样性
人口将使我们能够确定身体铅负担是否
非裔美国和西班牙裔女性的比例高于白人女性。
我们还将评估身体铅负担较高的女性是否
基线身体铅比基线身体铅较低的女性动员更多的铅
负担。
充足的铁储备已被证明可以防止铅吸收
因此,可能会防止铅动员期间
怀孕。 这项研究将调查铁储存对身体的影响
铅的负担有两种方式。 首先,我们要确定铁含量是否较高
通过血清铁蛋白水平评估的储存量可预测较低的身体负担
铅。 其次,我们会判断铁店的等级是否
通过比较血清铁蛋白影响妊娠期间的铅动员
前后骨、血和血浆铅测量水平
怀孕。
这项研究将首次对
假设骨骼铅动员发生在怀孕期间和
哺乳期。调查应提供重要的见解
长期接触环境铅对健康的潜在影响
孕妇、通过母乳喂养发育的胎儿和婴儿。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gertrud S. Berkowitz其他文献
Oral contraceptive use and fibrocystic breast disease among pre- and postmenopausal women.
绝经前和绝经后妇女的口服避孕药使用和纤维囊性乳腺疾病。
- DOI:
10.1093/oxfordjournals.aje.a113878 - 发表时间:
1984 - 期刊:
- 影响因子:5
- 作者:
Gertrud S. Berkowitz;Jennifer L. Kelsey;Virginia A. LiVolsi;Theodore R. Holford;Maria J. Merino;Sharon I. Ort;Theresa Z. O'Connor;Ira S. Goldenberg;C. White - 通讯作者:
C. White
Morbidity of failed labor in patients with prior cesarean section
- DOI:
10.1016/0002-9378(92)91729-t - 发表时间:
1992-12-01 - 期刊:
- 影响因子:
- 作者:
Joanne Stone;Charles J. Lockwood;Gertrud S. Berkowitz;Lauren Lynch;Manuel Alvarez;Robert H. Lapinski;Richard L. Berkowitz - 通讯作者:
Richard L. Berkowitz
Xenobiotic metabolism genes and the risk of recurrent spontaneous abortion.
异生物质代谢基因和复发性自然流产的风险。
- DOI:
10.1097/00001648-199603000-00018 - 发表时间:
1996 - 期刊:
- 影响因子:5.4
- 作者:
Ari Hirvonen;Jack A. Taylor;Allen J. Wilcox;Gertrud S. Berkowitz;Beth S. Schachter;Carlos A. Chaparro;Douglas A. Bell - 通讯作者:
Douglas A. Bell
Umbilical and uterine artery flow velocity waveforms. Effect of the sampling site on Doppler ratios.
脐动脉和子宫动脉血流速度波形。
- DOI:
10.7863/jum.1989.8.4.171 - 发表时间:
1989 - 期刊:
- 影响因子:2.3
- 作者:
K. Mehalek;J. Rosenberg;Gertrud S. Berkowitz;U. Chitkara;Richard L. Berkowitz - 通讯作者:
Richard L. Berkowitz
Gertrud S. Berkowitz的其他文献
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{{ truncateString('Gertrud S. Berkowitz', 18)}}的其他基金
Pesticides/Enodcrine Disruptors/Childhood Growth/Develop
农药/内分泌干扰物/儿童生长/发育
- 批准号:
6960219 - 财政年份:2004
- 资助金额:
$ 8.37万 - 项目类别:
Organochlorine exposure, genetic polymorphism and Parkinson's disease
有机氯暴露、遗传多态性与帕金森病
- 批准号:
6587642 - 财政年份:2002
- 资助金额:
$ 8.37万 - 项目类别:
Organochlorine exposure, genetic polymorphism and Parkinson's disease
有机氯暴露、遗传多态性与帕金森病
- 批准号:
6578820 - 财政年份:2002
- 资助金额:
$ 8.37万 - 项目类别:
EXPOSURE OF INDOOR PESTICIDES & PCBS--EFFECTS ON GROWTH & NEURODEVELOPMENT
接触室内农药
- 批准号:
6589554 - 财政年份:2001
- 资助金额:
$ 8.37万 - 项目类别:
EXPOSURE OF INDOOR PESTICIDES & PCBS--EFFECTS ON GROWTH & NEURODEVELOPMENT
接触室内农药
- 批准号:
6564420 - 财政年份:2001
- 资助金额:
$ 8.37万 - 项目类别:
EXPOSURE OF INDOOR PESTICIDES & PCBS--EFFECTS ON GROWTH & NEURODEVELOPMENT
接触室内农药
- 批准号:
6504078 - 财政年份:2000
- 资助金额:
$ 8.37万 - 项目类别:
EXPOSURE OF INDOOR PESTICIDES & PCBS--EFFECTS ON GROWTH & NEURODEVELOPMENT
接触室内农药
- 批准号:
6410383 - 财政年份:2000
- 资助金额:
$ 8.37万 - 项目类别:
NEUROPHYSIOLOGIC DYSFUNCTION, LEAD MOBILIZATION, AND MENOPAUSE
神经生理功能障碍、导线动员和更年期
- 批准号:
6344824 - 财政年份:1999
- 资助金额:
$ 8.37万 - 项目类别:
NEUROPHYSIOLOGIC DYSFUNCTION, LEAD MOBILIZATION, AND MENOPAUSE
神经生理功能障碍、导线动员和更年期
- 批准号:
6314566 - 财政年份:1999
- 资助金额:
$ 8.37万 - 项目类别:
LEAD MOBILIZATION DURING PREGNANCY AND LACTATION IN URBAN WOMEN
城市女性孕期和哺乳期的铅动员
- 批准号:
6106450 - 财政年份:1999
- 资助金额:
$ 8.37万 - 项目类别:
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