CORE--DATA COLLECTION, MANAGEMENT, AND ANALYSIS

数据收集、管理和分析核心(数据核心)有两个主要目标：1)启动和维持不孕症队列；2)向项目调查人员提供技术专长和支助。不孕症队列将包括620对夫妇，他们在旧金山湾区选定的不孕不育诊所接受初步咨询。队列成员将在任何抗逆转录病毒疗法尝试之前、最初的抗逆转录病毒疗法尝试之后以及在6、12和18个月的随访中接受采访。数据核心与发起和维持不孕症队列有关的责任包括：受试者征聘、登记和跟踪；培训面谈人员和病历摘要；安排和进行受试者面谈；进行病历审查以及创建克隆和编辑的数据库。该数据矿场还将在仪器开发和测试、数据收集以及一次和二次数据分析等方面向项目调查人员提供技术专门知识和支助。方案项目中包括的三个项目将使用不孕不育队列作为其主要数据来源；所有四个拟议项目都有概念联系，需要重叠的数据相关咨询资源，而且所有项目都有重叠的技术专长和支助需求。将资源集中到一个中央单位将使项目能够获得更广泛的人力和其他资源，并建立一个允许最大限度合作努力的基础设施，从而丰富拟议的研究。数据核心将由一名主任、作为专业人员的首席调查人员和共享研究人员组成。专业人员在确保项目成功的必要领域表现出专业知识，包括相关的科学领域，与跨学科团队进行合作研究的经验，项目项目和中心赠款的经验，与不孕不育提供者和工作人员的成功合作历史以及接触不孕不育患者的机会，以及模范的领导经验。

The Core for Data Collection, Management, and Analysis (Data Core) has two primary objectives: 1) to initiate and maintain the Infertility Cohort, and 2) to provide technical expertise and support to project investigators. The Infertility Cohort will include 620 couples who are seen for an initial consultation visit at selected infertility practices in the Bay Area. Cohort Members will be interviewed prior to any ART attempts, following the initial ART attempt, and at 6, 12, and 18 month follow-ups. Responsibilities of the Data Core related to initiating and maintain the Infertility Cohort include subject recruitment, enrollment and tracking; training of interviewers and medical record abstractors; scheduling and conducting subject interviews; conducting medical record reviews and creation of a cloned and edited database. The Data ore will also provide technical expertise and support to project investigators in the form of instrument development and testing, data collection, and analysis of primary and secondary data. Three of the projects included in the program project will use the Infertility Cohort as its primary data source; all four of the proposed projects have conceptual linkages requiring overlapping data-related consultative resources, and all of the projects have overlapping technical expertise and support needs. Pooling resources into a central unit will enrich the proposed research by allowing projects access to a greater range of human and other resources, and by creating an infrastructure that will allow for maximum collaborative effort. The Data Core will be staffed by a Director, principal investigators who serve as professional personnel, and shared research personnel. Professional staff have demonstrated expertise in the areas necessary to ensure project success, including the scientific areas of relevance, the conduct of collaborative research with interdisciplinary teams, experience with program projects and center grants, a history of successful collaboration with infertility providers and staff and access to infertile patients, and exemplary leadership experience.