PSYCHOLOGICAL CONSEQUENCES OF ASSISTED REPRODUCTIVE TECHNOLOGY FAILURE

辅助生殖技术失败的心理后果

• 批准号: 6221599
• 负责人: NANCY E ADLER
• 金额: $ 34.29万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-21 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6221599
• 关键词: angers; anxiety; assistive reproductive technique; behavior prediction; behavioral /social science research tag; child foster care /adoption; clinical depression; clinical research; cryopreservation; decision making; dyadic interaction; experience; fertility; fertilization; human subject; in vitro fertilization; interview; longitudinal human study; mental disorder diagnosis; outcomes research; psychological models; psychological stressor; spouses; success; women's health

The proposed research will be the first large prospective study of the psychological consequences associated with failure (particularly repeated failure) of assisted reproductive technologies (ARTs). Although there has been much concern about how ART failures affect individuals and couples, the current research literature contains more gaps than answers. The specific aims of this research are to: 1) determine the extent of psychological and marital distress and of clinically diagnosable psychiatric disorders ("psychological outcomes") in patients and their husbands following ART failure(s), 2) compare the psychological outcomes of patients and their husbands who remain childless after ART failure(s) to those who experience other treatment and child-related outcomes, including not pursuing ART, adopting a child, and having a child as a result of treatment and 3) use a vulnerability-stress model to predict which patients and husbands will experience poor psychological outcomes in response to ART failure(s) so that those individuals can be targeted for supportive interventions. A cohort of 620 couples seeing an ART physician for an initial consultation for their first ART cycle will be interviewed and followed over the subsequent 18 month period regardless of their treatment trajectory. All cohort members will participate in an initial interview prior to any ART attempts during which individual vulnerability factors will be assessed. All cohort members will then participate in a post-results interview two weeks after their first cycle if one is initiated, and follow- up interviews 6, 12, and 18 months later, during which psychological outcomes will be assessed. Those not initiating ARTs within 3 months of the initial interview will be re-interviewed 6, 12, 18 months later. The findings of this study will guide the development of assessment and intervention protocols for couples using and considering ARTs.

拟议的研究将是第一个与辅助生殖技术（ARTs）失败（特别是反复失败）相关的心理后果的大型前瞻性研究。尽管人们非常关注抗逆转录病毒治疗失败对个人和夫妇的影响，但目前的研究文献包含的空白多于答案。本研究的具体目的是：1)确定抗逆转录病毒治疗失败后患者及其丈夫的心理和婚姻困扰程度以及临床诊断的精神障碍（“心理结果”）；2)将抗逆转录病毒治疗失败后仍无子女的患者及其丈夫的心理结果与经历其他治疗和与儿童相关的结果（包括不寻求抗逆转录病毒治疗、收养儿童）的患者及其丈夫的心理结果进行比较；3)使用脆弱性-压力模型来预测哪些患者和丈夫在抗逆转录病毒治疗失败后会出现不良的心理结果，以便这些人可以成为支持干预措施的目标。将对620对夫妇进行访谈，并在随后的18个月期间对他们进行随访，无论他们的治疗轨迹如何。在进行抗逆转录病毒治疗之前，所有队列成员都将参加初步访谈，在此期间将评估个人脆弱性因素。所有队列成员将在他们的第一个周期开始后两周参加结果后访谈，并在6个月、12个月和18个月后进行随访访谈，在此期间将评估心理结果。未在首次面试后3个月内启动art的申请人将在6个月、12个月、18个月后重新进行面试。这项研究的结果将指导为使用和考虑抗逆转录病毒疗法的夫妇制定评估和干预方案。