SPECIFIC IMMUNITY DEVELOPMENT IN HUMAN NEWBORNS

人类新生儿的特异性免疫发育

• 批准号: 6114924
• 负责人: Anthony R. Hayward
• 金额: $ 1.99万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114924
• 关键词: T lymphocyte; active immunization; blood transfusion; cellular immunity; clinical research; developmental immunology; human subject; leukocyte activation disorder; microorganism immunology; neonatal intensive care; newborn human (0-6 weeks); premature infant human

This study looks at the outcome of Hepatitis B vaccination in prematures and term controls, testing the hypothesis that the T cell activation response to staph endotoxin B will predict the titer of antibody after 9 months. Cord blood is obtained at birth from prematures and a further four samples have been accrued in the past year. Permission to test the response, and to measure the antibody response to Hepatitis B is obtained at follow up. The total number of subjects being followed is currently 36, and the study will be closed to new entrants at this point.

这项研究着眼于早产儿和足月对照者接种乙型肝炎疫苗的结果，检验了 T 细胞对 B 型葡萄球菌内毒素的激活反应将预测 9 个月后抗体滴度的假设。 脐带血是在早产儿出生时采集的，去年又采集了四个样本。 随访时获得测试反应和测量乙型肝炎抗体反应的许可。 目前接受跟踪的受试者总数为 36 名，此时该研究将对新参与者关闭。